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Role of Interleukin 33 During Infection with Toxoplasmosis in Rheumatoid Arthritis Patients


Affiliations
1 Biology Department, College of Eductation (Ibn-Al-Haitham), University of Baghdad, Baghdad, Iraq
2 Biology Department , College of Science, Kirkuk University, Kirkuk, Iraq
     

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Toxoplasma gondii is avery common obligate intercellular parasite with highest infection rate among worlds populations. The Rheumatoid arthritis (RA) considered as an autoimmune disease characterized by loss immunological tolerance to self-antigens. Present study Aims to detection the seroprevalence of toxoplasmosis among RA patients and healthy control and evaluate concentrations of IL-33 to understand their role during infection. Seropositive cases of IgG was 36.7% percentage in RA patients with highest value of IgG 0.395 IU/ml while control group was 100% seronegative. Three cases only were seropositive to IgM with 1.17% and their mean 0.54 IU/ml.

IL-33 levels in RA patients with toxoplasmosis was highest 187.74 ± 33.24 pg/ml when compared with RA patients 107.88 ± 18.41 pg/ml and control group 55.59 ± 25.75 pg/ml ,there was a significant differences in comparison between studied groups.


Keywords

Toxoplasmosis, Rheumatoid Arthritis, IgG , IgM , IL-33.
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  • Role of Interleukin 33 During Infection with Toxoplasmosis in Rheumatoid Arthritis Patients

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Authors

Israa Kasim Al-Aubaidi
Biology Department, College of Eductation (Ibn-Al-Haitham), University of Baghdad, Baghdad, Iraq
Marwa Ali Al-Oqaily
Biology Department, College of Eductation (Ibn-Al-Haitham), University of Baghdad, Baghdad, Iraq
Sadia Shahab Hamad
Biology Department , College of Science, Kirkuk University, Kirkuk, Iraq

Abstract


Toxoplasma gondii is avery common obligate intercellular parasite with highest infection rate among worlds populations. The Rheumatoid arthritis (RA) considered as an autoimmune disease characterized by loss immunological tolerance to self-antigens. Present study Aims to detection the seroprevalence of toxoplasmosis among RA patients and healthy control and evaluate concentrations of IL-33 to understand their role during infection. Seropositive cases of IgG was 36.7% percentage in RA patients with highest value of IgG 0.395 IU/ml while control group was 100% seronegative. Three cases only were seropositive to IgM with 1.17% and their mean 0.54 IU/ml.

IL-33 levels in RA patients with toxoplasmosis was highest 187.74 ± 33.24 pg/ml when compared with RA patients 107.88 ± 18.41 pg/ml and control group 55.59 ± 25.75 pg/ml ,there was a significant differences in comparison between studied groups.


Keywords


Toxoplasmosis, Rheumatoid Arthritis, IgG , IgM , IL-33.



DOI: https://doi.org/10.37506/v14%2Fi1%2F2020%2Fijfmt%2F192953