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Synthesis and Characterization of Some Bis-Nitroaryl Pyrazolonesand Estimation of Their Anti-Bacterial and Anti-Fungal Activities


Affiliations
1 Chemistry Department, College of Education, University of Samarra, Iraq
2 Chemistry Department, College of Applied Sciences, University of Samarra, Iraq
     

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A simple and efficient one-pot synthesis of bicyclic nitro pyrazolone derivatives in traditional alcoholic solvents under refluxing conditions, The chemical structure of the synthesized derivatives was substantiated byFT-IR,1H NMR ,13C-NMRand CHNS analysis, All of these compounds of the series have been testedin vitro asantibacterial and antifungalagents against four types of organisms. The minimum and maximum inhibitory concentrations were determined against each organism.

Keywords

Pyrazolone, One-Pot Synthesis, Nitroaldehyde, Antibacterial Activity, Antifungi Activity.
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  • Synthesis and Characterization of Some Bis-Nitroaryl Pyrazolonesand Estimation of Their Anti-Bacterial and Anti-Fungal Activities

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Authors

MuathJabbar Tarfa Al-Abbasee
Chemistry Department, College of Education, University of Samarra, Iraq
Hamid J. Mohammad
Chemistry Department, College of Applied Sciences, University of Samarra, Iraq
Mawlood K. Mawlood
Chemistry Department, College of Education, University of Samarra, Iraq

Abstract


A simple and efficient one-pot synthesis of bicyclic nitro pyrazolone derivatives in traditional alcoholic solvents under refluxing conditions, The chemical structure of the synthesized derivatives was substantiated byFT-IR,1H NMR ,13C-NMRand CHNS analysis, All of these compounds of the series have been testedin vitro asantibacterial and antifungalagents against four types of organisms. The minimum and maximum inhibitory concentrations were determined against each organism.

Keywords


Pyrazolone, One-Pot Synthesis, Nitroaldehyde, Antibacterial Activity, Antifungi Activity.



DOI: https://doi.org/10.37506/v14%2Fi1%2F2020%2Fijfmt%2F192914