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Changes in Some Urinary Variables After Potassium Citrate Therapy In Patients With Recurrent Urinary Stone Disease In Tikrit City, Iraq


Affiliations
1 Assistant Professor of Urology, Tikrit University, College of Medicine, Iraq
2 Assistant Professor of Chemical, Pathology, Tikrit University, College of Medicine, Iraq
     

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Objective: To determine the effect of oral potassium citrate (k-citrate) on urinary calcium, magnesium, volume, and pH in patients with recurrent stone disease.

Patients & Method: Interventional clinical trial study was implemented from June 2016 to February 2019 in Tikrit city, Iraq. 94 patients with recurrent urinary stone disease were enrolled in this study. Oral k-citrate therapy was given to patients in a dose of 15 meq three times daily for 2 weeks. Patients instructed for 24 hours urinary collection before and after therapy. Urinary calcium, magnesium, volume, and pH were measured before and after therapy to examine the effect of k-citrate.

Results: Mean age was 38.5 (SD 17.4) years. Male patients were 64% while 36% of patients were females. Mean urinary calcium level decreased significantly after k-citrate therapy, p value < 0.001. Mean urinary volume and pH increased significantly after therapy, p value < 0.01 and < 0.05 respectively. No significant change was identified in mean urinary magnesium level after therapy, p value = 0.14. No adverse effects related to k-citrate therapy were reported by patients during study period.

Conclusion: Urinary volume and pH increased significantly in patients after potassium citrate therapy. Also k-citrate therapy significantly produced marked decrease in urinary calcium level. No change was observed in mean urinary magnesium level before and after k-citrate therapy. No adverse effects related to k-citrate therapy were reported by patients during study period.


Keywords

Urinary Calcium, Urinary Magnesium, Urinary Volume, Urinary pH, Potassium Citrate.
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  • Changes in Some Urinary Variables After Potassium Citrate Therapy In Patients With Recurrent Urinary Stone Disease In Tikrit City, Iraq

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Authors

Mohammed Mohsin Abdul-Aziz
Assistant Professor of Urology, Tikrit University, College of Medicine, Iraq
Nihad Nejres Hilal
Assistant Professor of Chemical, Pathology, Tikrit University, College of Medicine, Iraq
Mohanned Hussam Mohammed Saeed Alkumait
Assistant Professor of Urology, Tikrit University, College of Medicine, Iraq

Abstract


Objective: To determine the effect of oral potassium citrate (k-citrate) on urinary calcium, magnesium, volume, and pH in patients with recurrent stone disease.

Patients & Method: Interventional clinical trial study was implemented from June 2016 to February 2019 in Tikrit city, Iraq. 94 patients with recurrent urinary stone disease were enrolled in this study. Oral k-citrate therapy was given to patients in a dose of 15 meq three times daily for 2 weeks. Patients instructed for 24 hours urinary collection before and after therapy. Urinary calcium, magnesium, volume, and pH were measured before and after therapy to examine the effect of k-citrate.

Results: Mean age was 38.5 (SD 17.4) years. Male patients were 64% while 36% of patients were females. Mean urinary calcium level decreased significantly after k-citrate therapy, p value < 0.001. Mean urinary volume and pH increased significantly after therapy, p value < 0.01 and < 0.05 respectively. No significant change was identified in mean urinary magnesium level after therapy, p value = 0.14. No adverse effects related to k-citrate therapy were reported by patients during study period.

Conclusion: Urinary volume and pH increased significantly in patients after potassium citrate therapy. Also k-citrate therapy significantly produced marked decrease in urinary calcium level. No change was observed in mean urinary magnesium level before and after k-citrate therapy. No adverse effects related to k-citrate therapy were reported by patients during study period.


Keywords


Urinary Calcium, Urinary Magnesium, Urinary Volume, Urinary pH, Potassium Citrate.



DOI: https://doi.org/10.37506/v14%2Fi1%2F2020%2Fijfmt%2F192913