A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Chauhan, Rahul
- Isolated Thrombocytopenia in Pulmonary Tuberculosis: A Case Report and Review
Authors
1 Columbia Asia Hospital, Ghaziabad, U.P, IN
2 Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, U.P, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 84-86Abstract
Introduction: Isolated thrombocytopenia in association with childhood tuberculosis is a rare event and occasional reports are described in pediatric literature. We describe a case of isolated thrombocytopenia associated with active pulmonary tuberculosis in a three year old girl with no history of intake of anti tubercular drugs.
Case report: A three year old girl presented with low grade fever, decreased appetite, dry cough for six weeks and generalized cutaneous petechial rash for one day with no history of bleeding sites, hematuria or malena. Hematologic investigations, mantoux test and chest X-ray were advised.
Findings: Hematologic investigations revealed that TLC and DLC were within normal limits while platelets could not be demonstrated on peripheral blood smear.ESR was raised and mantoux test was positive. Chest X-ray revealed bilateral miliary shadows.
Treatment: The patient was treated successfully with anti tubercular drugs and a short steroid therapy.
Review: Above case was discussed in light of literature available in the matter.
Keywords
Thrombocytopenia, Peticheal Rash, Pulmonary Tuberculosis, ATT.
References
- Krishnamurthy S.,Yadav S. Immune thrombocytopenic purpura as a presentation of childhood tuberculosis. Indian J Pediatr2007; 74:853-55.
- Goldenberg AS: Hematologic abnormalities and mycobacterial infections in Tuberculosis. Edited by Rom WN, Garay S. New York, Litlle, Brown and Comp. 1996; 645-655.
- Mert A, Bilir M, Tabak F, Ozaras R, Ozturk R, Senturk H, Aki H, Seyhan N, Karayel T, Aktuglu Y: Miliary tuberculosis: clinical manifestations, diagnosis and outcome in 38 adults. Respirology 2001, 6:217-224.
- Tsuro K, Kojima H, Mitoro A, Yoshiji H, Fujimoto M, Umura M et al. Immune thrombocytopenic purpura associated with pulmonary tuberculosis. Intern Med 2006; 45 (11): 739-42.
- Ghobrial MW, Albornoz MA. Immune thrombocytopenia: a rare presenting manifestation of tuberculosis. Am J Hematol 2001; 67: 139-143.
- Coburn, R. J., England, J. M., Samson, D. M., Walford, D. M., Blowers, R., Chanarin, I., Levi, A. J. and Slavin, G. Tuberculosis and Blood Disorders. British Journal of Haematology 1973; 25: 793–799.
- Glasser RM, Walker RI, Herion JC. The significance of hematologic abnormalities in patients with tuberculosis. Arch Intern Med 1970; 125: 691-695.
- Jurak SS, Aster R, Sawaf H. Immune thrombocytopenia associated with tuberculosis. Clin Pediatr (Phila) 1983; 22: 318-319.
- Boots RJ, Roberts AW, McEvoy D. Immune thrombocytopenia complicating pulmonary tuberculosis: case report and investigation of mechanisms. Thorax1992; 47: 396-397.
- Enarson DA, Murray JF: Global epidemiology of tuberculosis. In Tuberculosis. Edited by Rom WN, Garay S. New York, Litlle, Brown and Comp. 1996:57-76.
- Aaron L, Saadoun D, Calatroni I, Launay O, Memain N, Vincent V, Marchal G, Dupont B, Bouchaud O, Valeyre D, Lortholay O: Tuberculosis in HIV-infected patients: a comprehensive review. Clin Microbiol Infect 2004: 388-398.
- Paolo WF Jr, Nosanchuk JD: Tuberculosis in New York city: recent lessons and a look ahead. Lancet Infect Dis 2004;4:287-293.
- Al-Majed SA,Al -Momen AK, Al-Kassimi FA, Al- Zeer A, Kambal AM, Baaqil H. Tuberculosis presenting as immune thrombocytopenic purpura. Acta Haematol.1995; 94: 135-138.
- Levy M, Cooper BA. Thrombocytopenic purpura associated with tuberculous lymphadenitis. Can Med Assoc J.1964; 90: 373-374.
- Verma S, Verma SK. Thrombocytopenic purpura with pulmonary tuberculosis: A case report. The Internet Journal of Pulmonary Medicine. 2008:9(2).
- Tongyoo S, Vilaichone W, Sukpanichnant S, et al. Thrombocytopenic purpura associated with miliary tuberculosis. J Med Assoc Thai.2003; 86: 976-980.
- Ozkalemkas F, Ali R, Ozkan A, et al. Tuberculosis presenting as immune thrombocytopenic purpura. Ann Clin Microbiol Antimicrob. 2004; 3: 16.
- Bakhshi S, Kabra M, Iyer VK, Arya LS. Thrombocytopenic purpura as a presenting manifestation of tubercular lymphadenitis. Indian J Pediatr.2003;70: 993-994.
- Singh SP, Misra GC, Prusty PK, Das RK. Tubercular lymphadenitis with purpura. J Indian Med Assoc.1986; 84: 247-249.