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A Study on Evaluation of Factors Contributing to Fatty Liver in Type 2 Diabetes Mellitus


Affiliations
1 Associate Professor Department of Medicine, GSL Medical College, NH-5, Lakshmipuram, Andhra Pradesh - 533294, India
2 Department of Medicine, GSL Medical College, NH5, Lakshmi Puram, A.P, India
3 Department of Pathology, Siddhartha Medical College, Vijayawada, A.P, India
4 Anil Diabetes Care, Red Cross Lane, Khaleelwadi, Nizamabad, A.P, India
     

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Background: As type 2 diabetes patients are prone to develop fatty liver which can predispose them to cirrhosis, we tried to evaluate the factors that contribute to development of fatty liver in diabetes.

Material and Method: We enrolled 137 type 2 diabetes patients, took anthropometric measurements like BMI, waist circumfrence and waist hip ratio. We subjected them to investigations like ultrasonography (USG) of abdomen, liver function tests and fasting lipid profile. Based on USG abdomen, we classified these patients into FL+(fatty liver ) group and FL-(non fatty liver) group. We analysed various factors that correlate with the development of fatty liver.

Results: Out of 137 type 2 diabetes patients, fatty liver was seen in 48 cases (35%). Cirrhosis was found in 2 cases and hepattocellular carcinoma in 1 case. FL+ group has statically significant high mean total cholesterol, LDL and triglycerides than FL- group. Age, duration of diabetes, gender and HBA1C did not show any statistical correlaton with the development of fatty liver. Among anthropometric measurements, waist circumfrence and BMI in FL+ group is higher than in FLgroup and showed statically significant correlation. Liver function tests like S.Bilirubin, AST, ALT, ALP were much higher in FL+ group than in FL- group but none of them have shown any statistical significance.

Conclusion: Simple measurements like BMI, waist circumfrence and routine laboratory tests like total cholesterol, LDL and triglycerides can be used as prognostic indicators for the development of fatty liver in type 2 diabetes patients.


Keywords

Fatty liver, Diabetes
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  • A Study on Evaluation of Factors Contributing to Fatty Liver in Type 2 Diabetes Mellitus

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Authors

N. S. R. C. Guptha
Associate Professor Department of Medicine, GSL Medical College, NH-5, Lakshmipuram, Andhra Pradesh - 533294, India
V. Suresh
Department of Medicine, GSL Medical College, NH5, Lakshmi Puram, A.P, India
V. Usha Bhargavi
Department of Pathology, Siddhartha Medical College, Vijayawada, A.P, India
T. Anil kumar
Anil Diabetes Care, Red Cross Lane, Khaleelwadi, Nizamabad, A.P, India
S. V. R Murthy
Department of Medicine, GSL Medical College, NH5, Lakshmi Puram, A.P, India

Abstract


Background: As type 2 diabetes patients are prone to develop fatty liver which can predispose them to cirrhosis, we tried to evaluate the factors that contribute to development of fatty liver in diabetes.

Material and Method: We enrolled 137 type 2 diabetes patients, took anthropometric measurements like BMI, waist circumfrence and waist hip ratio. We subjected them to investigations like ultrasonography (USG) of abdomen, liver function tests and fasting lipid profile. Based on USG abdomen, we classified these patients into FL+(fatty liver ) group and FL-(non fatty liver) group. We analysed various factors that correlate with the development of fatty liver.

Results: Out of 137 type 2 diabetes patients, fatty liver was seen in 48 cases (35%). Cirrhosis was found in 2 cases and hepattocellular carcinoma in 1 case. FL+ group has statically significant high mean total cholesterol, LDL and triglycerides than FL- group. Age, duration of diabetes, gender and HBA1C did not show any statistical correlaton with the development of fatty liver. Among anthropometric measurements, waist circumfrence and BMI in FL+ group is higher than in FLgroup and showed statically significant correlation. Liver function tests like S.Bilirubin, AST, ALT, ALP were much higher in FL+ group than in FL- group but none of them have shown any statistical significance.

Conclusion: Simple measurements like BMI, waist circumfrence and routine laboratory tests like total cholesterol, LDL and triglycerides can be used as prognostic indicators for the development of fatty liver in type 2 diabetes patients.


Keywords


Fatty liver, Diabetes