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Comparative Study of Response on Fever, Regression of Spleen and Liver Size by Treatment with I.v. Amphotericin B and Oral Miltefosine in Cases of Visceral Leishmaniasis


Affiliations
1 Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, India
2 Department of Pharmacology, Patna Medical College, Patna, Bihar, India
3 Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, India
4 Department of Biochemistry, Saraswati Institute of Medical Sciences, Hapur, UP, India
     

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This study was designed to compare the clinical cure produced by two most commonly used drugs i.v. Amphotericin B and oral Miltefosine in cases of visceral leishmaniasis. It was an observational and cross-sectional study. This study was conducted on two groups A and B, each had fifty patients and given I.V. Amphotericin B and oral Miltefosine respectively. 100% of cases became afebrile by 12th day in group A while by 14th day in group B. Reduction in mean size of spleen was significant (p<0.01) at 15th day in group A patients while by 22nd day (p<0.05) in group B. 100% of cases had non palpable spleen after 22nd day till the end of 6th month in group A but remained palpable till 6th month in 4 cases in group B. Reduction in mean size of liver was significant (p<0.05) on 15th day in group A while 22nd day (p<0.05) in group B patients. Liver was not palpable after 22nd day of treatment in group A while in group B it was not palpable after 2nd month. These results suggest that the clinical cure achieved in terms of response on fever and rate of spleen and liver regression in group A patients were more faster than group B patients.

Keywords

I.V. Amphotericin B, Oral Miltefosine, Response on Fever, Regression of Spleen and Liver Size
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  • Comparative Study of Response on Fever, Regression of Spleen and Liver Size by Treatment with I.v. Amphotericin B and Oral Miltefosine in Cases of Visceral Leishmaniasis

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Authors

Kumar Manish
Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, India
Ranjana
Department of Pharmacology, Patna Medical College, Patna, Bihar, India
J. R. Keshari
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, India
Rai Yogesh Kumar
Department of Biochemistry, Saraswati Institute of Medical Sciences, Hapur, UP, India
Sinha Kumari Indu
Department of Pharmacology, Patna Medical College, Patna, Bihar, India

Abstract


This study was designed to compare the clinical cure produced by two most commonly used drugs i.v. Amphotericin B and oral Miltefosine in cases of visceral leishmaniasis. It was an observational and cross-sectional study. This study was conducted on two groups A and B, each had fifty patients and given I.V. Amphotericin B and oral Miltefosine respectively. 100% of cases became afebrile by 12th day in group A while by 14th day in group B. Reduction in mean size of spleen was significant (p<0.01) at 15th day in group A patients while by 22nd day (p<0.05) in group B. 100% of cases had non palpable spleen after 22nd day till the end of 6th month in group A but remained palpable till 6th month in 4 cases in group B. Reduction in mean size of liver was significant (p<0.05) on 15th day in group A while 22nd day (p<0.05) in group B patients. Liver was not palpable after 22nd day of treatment in group A while in group B it was not palpable after 2nd month. These results suggest that the clinical cure achieved in terms of response on fever and rate of spleen and liver regression in group A patients were more faster than group B patients.

Keywords


I.V. Amphotericin B, Oral Miltefosine, Response on Fever, Regression of Spleen and Liver Size