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Status of Antioxidants Vitamin and Plasma Malondialdehyde (MDA) in Sickle Cell Anaemia Patients of Chhattisgarh Region


Affiliations
1 Demonstrator Dept. of Biochemistry, CIMS, Bilaspur, C.G., India
2 Dept of Biochemistry, G.R.M.C., Gwalior M.P., India
3 Demonstrator Dept. of Biochemistry, CIMS, Bilaspur, (C.G.), India
4 Dept of Physiology, G.R.M.C., Gwalior M.P., India
5 Dept of Biochemistry, CIMS, Bilaspur C.G.
     

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Background: Sickle cell spontaneously generates approximately two times more amount of reactive oxygen species. Lipid per oxidation has a major role in the pathophysiology of sickle cell anaemia, this may overwhelm the antioxidant defence system. Therefore, the study was undertaken to evaluate the levels of plasma Malondialdehyde (MDA), and antioxidants vitamins.

Material and Method: The present study was carried out in the Department of Biochemistry, Chhattisgarh Institute of Medical Sciences, Bilaspur, Chhattisgarh. Total eighty subjects were age between 15-35 years both male and female was selected for this study.

Results: We found significantly (P<0.001) elevated plasma MDA level and the antioxidants vitamins level were reduced significantly (P<0.001) in homozygous sickle cell cases as compared to controls.

Conclusion: These observations provide the evidence of imbalance between oxidant and antioxidant status leading to chronic oxidative stress. Therefore supplementation with antioxidants vitamin may ameliorate some of the sickle cell symptoms and improve quality of life.


Keywords

MDA - Malondialdehyde, SCA - Sickle cell Anemia, Antioxidants
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  • Status of Antioxidants Vitamin and Plasma Malondialdehyde (MDA) in Sickle Cell Anaemia Patients of Chhattisgarh Region

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Authors

Vikas Kumar Gupta
Demonstrator Dept. of Biochemistry, CIMS, Bilaspur, C.G., India
Neelima Singh
Dept of Biochemistry, G.R.M.C., Gwalior M.P., India
Prashant Nigam
Demonstrator Dept. of Biochemistry, CIMS, Bilaspur, (C.G.), India
Jayant Shah
Dept of Physiology, G.R.M.C., Gwalior M.P., India
S. K. B. Patil
Dept of Biochemistry, CIMS, Bilaspur C.G.

Abstract


Background: Sickle cell spontaneously generates approximately two times more amount of reactive oxygen species. Lipid per oxidation has a major role in the pathophysiology of sickle cell anaemia, this may overwhelm the antioxidant defence system. Therefore, the study was undertaken to evaluate the levels of plasma Malondialdehyde (MDA), and antioxidants vitamins.

Material and Method: The present study was carried out in the Department of Biochemistry, Chhattisgarh Institute of Medical Sciences, Bilaspur, Chhattisgarh. Total eighty subjects were age between 15-35 years both male and female was selected for this study.

Results: We found significantly (P<0.001) elevated plasma MDA level and the antioxidants vitamins level were reduced significantly (P<0.001) in homozygous sickle cell cases as compared to controls.

Conclusion: These observations provide the evidence of imbalance between oxidant and antioxidant status leading to chronic oxidative stress. Therefore supplementation with antioxidants vitamin may ameliorate some of the sickle cell symptoms and improve quality of life.


Keywords


MDA - Malondialdehyde, SCA - Sickle cell Anemia, Antioxidants