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Oxidant and Antioxidant Status in CRF


Affiliations
1 Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-14, India
2 Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-14, Iceland
3 Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
4 Dept of Radiology, Narayan Medical College & Hospital, Sasaram, India
     

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Oxidative stress plays a significant role in pathogenesis of chronic renal failure (CRF). Redox imbalance caused by increased ROS production and/ or reduced antioxidant reserve, leading to pathological consequences including damage to proteins, lipids and DNA. The present paper focuses on the extent of free radical damage on lipid (measured as malondialdehyde, MDA) and effect on antioxidant defense mechanism (measured as vitamin C) in the serum of CRF patients predialytically.40 cases and 40 controls between age group of 25 - 60 were taken. The level of MDA, creatinine, blood urea nitrogen was significantly increased, antioxidant vitamin levels were decreased in CRF patients as compared to normal subjects.The elevated MDA level can lead to lipid peroxidation and can also promote the complication of CRF. The antioxidant levels were decreased , so these patients can be supplemented with antioxidant vitamins for preventing lipid peroxidation and occurance of complication.

Keywords

Antioxidant Vitamins, Chronic Renal Failure, MDA, Oxidative Stress
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  • Oxidant and Antioxidant Status in CRF

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Authors

Ratna Priya
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-14, India
J. R. Keshri
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-14, India
Uday Kumar
Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna-14, Iceland
Anand Sharan
Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
Rekha Kumari
Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
Chandan Kishore
Dept of Radiology, Narayan Medical College & Hospital, Sasaram, India

Abstract


Oxidative stress plays a significant role in pathogenesis of chronic renal failure (CRF). Redox imbalance caused by increased ROS production and/ or reduced antioxidant reserve, leading to pathological consequences including damage to proteins, lipids and DNA. The present paper focuses on the extent of free radical damage on lipid (measured as malondialdehyde, MDA) and effect on antioxidant defense mechanism (measured as vitamin C) in the serum of CRF patients predialytically.40 cases and 40 controls between age group of 25 - 60 were taken. The level of MDA, creatinine, blood urea nitrogen was significantly increased, antioxidant vitamin levels were decreased in CRF patients as compared to normal subjects.The elevated MDA level can lead to lipid peroxidation and can also promote the complication of CRF. The antioxidant levels were decreased , so these patients can be supplemented with antioxidant vitamins for preventing lipid peroxidation and occurance of complication.

Keywords


Antioxidant Vitamins, Chronic Renal Failure, MDA, Oxidative Stress