International Journal of Contemporary Medicine

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Comparative Study of Lipid Profile in Chronic Alcoholics and Non Alcoholics in a Tertiary Care Hospital Bangalore, South India


Affiliations
1 Department of Biochemistry, Sri Jayadeva Institute of Cardiovascular Science & Research Bangalore, Karnataka, India
2 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Science, Kanchipuram, Tamilnadu, India
3 Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, India
4 Department of Community Medicine, S.S. Institute of Medical Sciences & Research Centre, Davangere, Karnataka, India
5 Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, India
     

   Subscribe/Renew Journal


Background and Objectives: Alcoholism is a major threat to public health in both developed and developing countries. Over last 30-40 years alcohol consumption has increased in quantity and frequency. Alcohol use predisposes subjects to changes in lipid profile which are associated with coronary risk. Method: 30 alcoholic males were compared with 30 non alcoholic males. Alcohol drinking history was assessed by interview and questionnaire and lipid profile was done measuring total cholesterol, triglycerides, HDL, VLDL & LDL. Results: There were significant rise in TC, TGL ,HDL , LDL and VLDL of chronic alcoholics compared with non alcoholics with p value 0.001, <0.001, 0.004, 0.290, <0.001, respectively. Lipid profile was compared among moderate and heavy drinkers and found increased levels of TC, TGL, LDL & VLDL with p value <0.001, 0.001, 0.002 & 0.001 respectively in heavy drinkers. There is decrease in HDL cholesterol among heavy drinkers compared with moderate drinkers, p value 0.011 which is significant. But remains elevated compared to non alcoholics. Conclusion: This study shows that alcohol intake increases the level of lipid parameters. Moderate alcohol intake increases HDL cholesterol whereas heavy alcohol consumption increases TC,TGL,LDL & VLDL and decreases HDL.

Keywords

Lipid Profile, Moderate Drinkers, Heavy Drinkers.
Subscription Login to verify subscription
User
Notifications
Font Size


  • J. Kishore’s National Health Programs of India, Pg. 384-385

  • Morse & Flavin. The definition of alcoholism , August 26, 1993. 262 (8) :1012- 1014.

  • Vaswani M, Rao RV. Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Indian J Med Sci, 2005; Vol 59: 423-430.

  • Sheila Sherlock and James Dooley. Alcohol and the Liver, Diseases of Liver and Biliary system,11th edition, Blackwell publications, London: 384-385.

  • E Baraona and C S Lieber. Effects of ethanol on lipid metabolism.

  • The Lancet vol 310, Issue 8030, 23. July 1977. Page 153-155

  • Journal of lipid res. 1998. 39:2319-2328

  • Drago S et al. study of lipid profile in chronic alcoholics. The indian practitioner 2002 Jan; 55(1):5-8.

  • Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Vol 59 oct 2005, No.10.

  • Arun lakshmipathy et al. unusual lipid and metabolic abnormalities secondary to alcohol abuse Case report, Hospital Physician aug 2004.

  • Lawrence Feinman and Charles S Lieber.Ethanol and lipid metabolism. American journal of clinical nutrition.

  • Barboriak J J & R C Meade.1970. Effects of alcohol on gastric emptying in man. Am. J. Clin. Nutr.23: 1151-1153.

  • Muller P, et al. Hypertriglyceridemia secondary to liver disease. Eur.J.Clin.Invest.4:419-428.


Abstract Views: 612

PDF Views: 0




  • A Comparative Study of Lipid Profile in Chronic Alcoholics and Non Alcoholics in a Tertiary Care Hospital Bangalore, South India

Abstract Views: 612  |  PDF Views: 0

Authors

K C Sheethal
Department of Biochemistry, Sri Jayadeva Institute of Cardiovascular Science & Research Bangalore, Karnataka, India
Swetha Singaravelu
Department of Biochemistry, Karpaga Vinayaga Institute of Medical Science, Kanchipuram, Tamilnadu, India
Shanthakumari
Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, India
L Hamsa
Department of Community Medicine, S.S. Institute of Medical Sciences & Research Centre, Davangere, Karnataka, India
Shwetha
Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, India
Hemalatha
Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, India

Abstract


Background and Objectives: Alcoholism is a major threat to public health in both developed and developing countries. Over last 30-40 years alcohol consumption has increased in quantity and frequency. Alcohol use predisposes subjects to changes in lipid profile which are associated with coronary risk. Method: 30 alcoholic males were compared with 30 non alcoholic males. Alcohol drinking history was assessed by interview and questionnaire and lipid profile was done measuring total cholesterol, triglycerides, HDL, VLDL & LDL. Results: There were significant rise in TC, TGL ,HDL , LDL and VLDL of chronic alcoholics compared with non alcoholics with p value 0.001, <0.001, 0.004, 0.290, <0.001, respectively. Lipid profile was compared among moderate and heavy drinkers and found increased levels of TC, TGL, LDL & VLDL with p value <0.001, 0.001, 0.002 & 0.001 respectively in heavy drinkers. There is decrease in HDL cholesterol among heavy drinkers compared with moderate drinkers, p value 0.011 which is significant. But remains elevated compared to non alcoholics. Conclusion: This study shows that alcohol intake increases the level of lipid parameters. Moderate alcohol intake increases HDL cholesterol whereas heavy alcohol consumption increases TC,TGL,LDL & VLDL and decreases HDL.

Keywords


Lipid Profile, Moderate Drinkers, Heavy Drinkers.

References