International Journal of Contemporary Medicine

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Role of Bone Marrow Study in Malignant Disorders: A Clinicopathological Study of 185 Patients


Affiliations
1 Department of Pathology, Mayo institute of medical sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, India
2 Department of Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India
3 Department of Pathology, Dr. B. R. Sur Homeopathic Medical College and Hospital and Research center, New Delhi, India
4 Department of Pathology, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India
5 Santosh Medical College, Ghaziabad, Uttar Pradesh, India
     

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Introduction: Bone marrow is a reservoir of stem cells and is the site of origin of numerous primary hematological malignancies and is commonly infiltrated by malignant cells in non-hematological malignancies in advanced stages. Objectives: The present study (2002 - 2012) has been aimed to report our experience with one hundred eighty five (185) patients from North India. A comparative study of bone marrow aspiration (BMA) and bone marrow biopsy (BMB) was done simultaneously, where the clinical history was correlated before and after chemotherapy and radiotherapy. Material and Method: In our study we have included cases of malignant disorders (hematological malignancies and non-hematological malignancies). In each case bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined. Results: In our study we have included cases of hematological malignancies (Leukemia, Multiple Myeloma and Malignant Lymphoma) and non-hematological malignancies (Carcinoma of Breast, Prostate, Lung, Kidney, Urinary bladder, GIT, Thyroid, Round cell tumors and Indeterminate tumors). In hematological malignancies, non-Hodgkin's lymphomas (NHL) were maximum thirty cases (28.03%) and hairy cell leukemia (HCL) one case (0.93%). In non-hematological malignancies or primary tumors, there were maximum cases of breast carcinoma, twenty four cases (30.76%) and minimum two cases of thyroid carcinoma (02.56%). Conclusion: Malignant disorders were more prevalent in males and were seen in all the age groups. In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Bone marrow biopsy found to be more informative in lymphoma and Metastatic tumors Bone marrow involvement indicated poor prognosis in metastatic tumors except in seven cases (18.42%) of malignant lymphoma. There was no complication of the procedure even in cases of thrombocytopenia.

Keywords

Bone Marrow, Hematological Malignancies, Non-Hematological Malignancies
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  • Role of Bone Marrow Study in Malignant Disorders: A Clinicopathological Study of 185 Patients

Abstract Views: 287  |  PDF Views: 2

Authors

Prem K. Garg
Department of Pathology, Mayo institute of medical sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, India
Ajoy Deshmukh
Department of Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India
Kiran G. Mahabole
Department of Pathology, Dr. B. R. Sur Homeopathic Medical College and Hospital and Research center, New Delhi, India
Geeta Deshmukh
Department of Pathology, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India
Jyotsna Madan
Santosh Medical College, Ghaziabad, Uttar Pradesh, India

Abstract


Introduction: Bone marrow is a reservoir of stem cells and is the site of origin of numerous primary hematological malignancies and is commonly infiltrated by malignant cells in non-hematological malignancies in advanced stages. Objectives: The present study (2002 - 2012) has been aimed to report our experience with one hundred eighty five (185) patients from North India. A comparative study of bone marrow aspiration (BMA) and bone marrow biopsy (BMB) was done simultaneously, where the clinical history was correlated before and after chemotherapy and radiotherapy. Material and Method: In our study we have included cases of malignant disorders (hematological malignancies and non-hematological malignancies). In each case bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined. Results: In our study we have included cases of hematological malignancies (Leukemia, Multiple Myeloma and Malignant Lymphoma) and non-hematological malignancies (Carcinoma of Breast, Prostate, Lung, Kidney, Urinary bladder, GIT, Thyroid, Round cell tumors and Indeterminate tumors). In hematological malignancies, non-Hodgkin's lymphomas (NHL) were maximum thirty cases (28.03%) and hairy cell leukemia (HCL) one case (0.93%). In non-hematological malignancies or primary tumors, there were maximum cases of breast carcinoma, twenty four cases (30.76%) and minimum two cases of thyroid carcinoma (02.56%). Conclusion: Malignant disorders were more prevalent in males and were seen in all the age groups. In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Bone marrow biopsy found to be more informative in lymphoma and Metastatic tumors Bone marrow involvement indicated poor prognosis in metastatic tumors except in seven cases (18.42%) of malignant lymphoma. There was no complication of the procedure even in cases of thrombocytopenia.

Keywords


Bone Marrow, Hematological Malignancies, Non-Hematological Malignancies

References