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Size Matters:Molecular Weight Specificity of Hyaluronan Effects in Cell Biology


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1 Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
 

Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.
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  • Size Matters:Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

Abstract Views: 56  |  PDF Views: 0

Authors

Jaime M. Cyphert
Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
Carol S. Trempus
Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
Stavros Garantziotis
Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States

Abstract


Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.