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Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery


Affiliations
1 Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States
2 Department of Biomedical Engineering/ND20, Cleveland Clinic, Cleveland, OH, United States
3 Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, United States
 

The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoproteins, proteoglycans, and glycosaminoglycans that dictates tissue architecture. Cancer tissue invasive processes progress by various oncogenic strategies, including interfering with ECM molecules and their interactions with invasive cells. In this review, we describe how the ECM components, proteoglycans and glycosaminoglycans, influence tumor cell signaling. In particular this review describes how the glycosaminogly can hyaluronan (HA) and its major receptor CD44 impact invasive behavior of tumor cells, and provides useful insight when designing new therapeutic strategies in the treatment of cancer.
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  • Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery

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Authors

Suniti Misra
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States
Vincent C. Hascall
Department of Biomedical Engineering/ND20, Cleveland Clinic, Cleveland, OH, United States
Ilia Atanelishvili
Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, United States
Ricardo Moreno Rodriguez
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States
Roger R. Markwald
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States
Shibnath Ghatak
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, United States

Abstract


The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoproteins, proteoglycans, and glycosaminoglycans that dictates tissue architecture. Cancer tissue invasive processes progress by various oncogenic strategies, including interfering with ECM molecules and their interactions with invasive cells. In this review, we describe how the ECM components, proteoglycans and glycosaminoglycans, influence tumor cell signaling. In particular this review describes how the glycosaminogly can hyaluronan (HA) and its major receptor CD44 impact invasive behavior of tumor cells, and provides useful insight when designing new therapeutic strategies in the treatment of cancer.