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Immunomodulatory Effects of Chitotriosidase Enzyme


Affiliations
1 Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven, KU Leuven, UZ Herestraat 49, P.O. Box 817, 3000 Leuven, Belgium
 

Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects extend far beyond innateimmunity. In the current review, we will try to explore the expanding spectrum of immunological roles played by chitotriosidase enzyme in human health and disease and will discuss its up-to-date clinical value.
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  • Immunomodulatory Effects of Chitotriosidase Enzyme

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Authors

Mohamed A. Elmonem
Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven, KU Leuven, UZ Herestraat 49, P.O. Box 817, 3000 Leuven, Belgium
Lambertus P. van den Heuvel
Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven, KU Leuven, UZ Herestraat 49, P.O. Box 817, 3000 Leuven, Belgium
Elena N. Levtchenko
Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven, KU Leuven, UZ Herestraat 49, P.O. Box 817, 3000 Leuven, Belgium

Abstract


Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects extend far beyond innateimmunity. In the current review, we will try to explore the expanding spectrum of immunological roles played by chitotriosidase enzyme in human health and disease and will discuss its up-to-date clinical value.