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Methylchloroisothiazolinone/Methylisothiazolinone and Methylisothiazolinone Sensitivity in Hungary


Affiliations
1 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest 1085, Hungary
 

Background: Due to allowing of methylisothiazolinone (MI) in cosmetics, cleaning products, and paints, an epidemic of MIhypersensitivity emerged. Patch testing Kathon CG (3:1 mixture of methylchloroisothiazolinone and methylisothiazolinone, MCI/MI) does not correctly detect MI contact allergy, due to the low concentration of MI in the test material. Methods: A retrospective survey was performed to estimate the prevalence of MCI/MI hypersensitivity in 14693 patients tested consecutively between 1993 and 2014. Moreover, currently 314 patients were prospectively tested with the allergens MCI/MI and with MI during one year. Results: MCI/MI hypersensitivity increased retrospectively from0.5% to 6.0%. By current prospective testing we detected 25 patients (8%) with MCI/MI and/or MI positive reactions. Out of the 25 patients 10 were only MCI/MI positive, 9 were only MI positive, and 6 were MCI/MI and MI positive. If MI had not been tested separately, MI contact allergy would have missed in 36% of all detected cases and in 2.8% of the total 314 patients. Conclusions:The frequency ofMCI/MI hypersensitivity is increasing also in Hungary. We confirm that, in order to detect MI contact allergy, it needs to be tested separately. A further increase of MI hypersensitivity might be expected in the future as products containing MI are still widely available.
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  • Methylchloroisothiazolinone/Methylisothiazolinone and Methylisothiazolinone Sensitivity in Hungary

Abstract Views: 88  |  PDF Views: 2

Authors

Gyorgyi Ponyai
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest 1085, Hungary
Ilona Nemeth
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest 1085, Hungary
Erzsebet Temesvari
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest 1085, Hungary

Abstract


Background: Due to allowing of methylisothiazolinone (MI) in cosmetics, cleaning products, and paints, an epidemic of MIhypersensitivity emerged. Patch testing Kathon CG (3:1 mixture of methylchloroisothiazolinone and methylisothiazolinone, MCI/MI) does not correctly detect MI contact allergy, due to the low concentration of MI in the test material. Methods: A retrospective survey was performed to estimate the prevalence of MCI/MI hypersensitivity in 14693 patients tested consecutively between 1993 and 2014. Moreover, currently 314 patients were prospectively tested with the allergens MCI/MI and with MI during one year. Results: MCI/MI hypersensitivity increased retrospectively from0.5% to 6.0%. By current prospective testing we detected 25 patients (8%) with MCI/MI and/or MI positive reactions. Out of the 25 patients 10 were only MCI/MI positive, 9 were only MI positive, and 6 were MCI/MI and MI positive. If MI had not been tested separately, MI contact allergy would have missed in 36% of all detected cases and in 2.8% of the total 314 patients. Conclusions:The frequency ofMCI/MI hypersensitivity is increasing also in Hungary. We confirm that, in order to detect MI contact allergy, it needs to be tested separately. A further increase of MI hypersensitivity might be expected in the future as products containing MI are still widely available.