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Altered Levels of Serum Zinc and Cadmium in Patients with Chronic Vesiculobullous Hand and Feet Dermatitis


Affiliations
1 Department of Dermatology, King George Medical University, Lucknow, Uttar Pradesh 226003, India
2 Department of Dermatology, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India
3 Department of Forensic Medicine, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India
4 Department of Radiodiagnosis, King George Medical University, Lucknow, Uttar Pradesh 226003, India
 

Micronutrients serve many important functions in our body and altered levels of heavy and trace metals are associated with cutaneous and systemic disorders. Vesicular palmoplantar eczema is an entity whose etiopathogenesis is a mystery. In this prospective case-noncase study blood levels of Zinc and Cadmium in 37 patients of chronic vesiculobullous hand dermatitis were estimated and compared with 40 noncases with similar age and gender distributions. Low serum Zinc levels were found in patients as compared to noncases.The mean difference of serum Zinc between the case and noncase groups was 27.26; the mean value of serum Zinc between the two groups was statistically significant (p < 0.0001). However, elevated Cadmium levels were detected in only 5 patients and in none of the noncases. The mean concentration of serum Cadmium was 2.32 ± 0.38 μg/dL, with a range of 1.90-2.80 μg/dL for the five cases in whom Cadmium was detected. Various toxic and trace metals can interact by influencing each other's absorption, retention, distribution, and bioavailability in the body. The clinical significance of this finding lies in the possible beneficial role of Zinc supplementation in the therapy of chronic vesiculobullous hand dermatitis.
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  • Altered Levels of Serum Zinc and Cadmium in Patients with Chronic Vesiculobullous Hand and Feet Dermatitis

Abstract Views: 98  |  PDF Views: 1

Authors

Swastika Suvirya
Department of Dermatology, King George Medical University, Lucknow, Uttar Pradesh 226003, India
Alpna Thakur
Department of Dermatology, King George Medical University, Lucknow, Uttar Pradesh 226003, India
S. S. Pandey
Department of Dermatology, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India
S. K. Tripathi
Department of Forensic Medicine, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India
Durgesh Kumar Dwivedi
Department of Radiodiagnosis, King George Medical University, Lucknow, Uttar Pradesh 226003, India

Abstract


Micronutrients serve many important functions in our body and altered levels of heavy and trace metals are associated with cutaneous and systemic disorders. Vesicular palmoplantar eczema is an entity whose etiopathogenesis is a mystery. In this prospective case-noncase study blood levels of Zinc and Cadmium in 37 patients of chronic vesiculobullous hand dermatitis were estimated and compared with 40 noncases with similar age and gender distributions. Low serum Zinc levels were found in patients as compared to noncases.The mean difference of serum Zinc between the case and noncase groups was 27.26; the mean value of serum Zinc between the two groups was statistically significant (p < 0.0001). However, elevated Cadmium levels were detected in only 5 patients and in none of the noncases. The mean concentration of serum Cadmium was 2.32 ± 0.38 μg/dL, with a range of 1.90-2.80 μg/dL for the five cases in whom Cadmium was detected. Various toxic and trace metals can interact by influencing each other's absorption, retention, distribution, and bioavailability in the body. The clinical significance of this finding lies in the possible beneficial role of Zinc supplementation in the therapy of chronic vesiculobullous hand dermatitis.