Open Access Open Access  Restricted Access Subscription Access

Postinfarct Left Ventricular Remodelling: a Prevailing Cause of Heart Failure


Affiliations
1 Cardiovascular Diseases Unit, Fondazione IRCCS CaGranda Ospedale Maggiore Policlinico, Department of Clinical and Community Sciences, University of Milan, Via F. Sforza 35, 20122 Milan, Italy
 

Heart failure is a chronic disease with high morbidity and mortality, which represents a growing challenge in medicine. A major risk factor for heart failure with reduced ejection fraction is a history of myocardial infarction. The expansion of a large infarct scar and subsequent regional ventricular dilatation can cause postinfarct remodelling, leading to significant enlargement of the left ventricular chamber. It has a negative prognostic value, because it precedes the clinical manifestations of heart failure. The characteristics of the infarcted myocardium predicting postinfarct remodelling can be studied with cardiac magnetic resonance and experimental imaging modalities such as diffusion tensor imaging can identify the changes in the architecture of myocardial fibers. This review discusses all the aspects related to postinfarct left ventricular remodelling: definition, pathogenesis, diagnosis, consequences, and available therapies, together with experimental interventions that show promising results against postinfarct remodelling and heart failure.
User
Notifications
Font Size

Abstract Views: 55

PDF Views: 0




  • Postinfarct Left Ventricular Remodelling: a Prevailing Cause of Heart Failure

Abstract Views: 55  |  PDF Views: 0

Authors

Alessio Galli
Cardiovascular Diseases Unit, Fondazione IRCCS CaGranda Ospedale Maggiore Policlinico, Department of Clinical and Community Sciences, University of Milan, Via F. Sforza 35, 20122 Milan, Italy
Federico Lombardi
Cardiovascular Diseases Unit, Fondazione IRCCS CaGranda Ospedale Maggiore Policlinico, Department of Clinical and Community Sciences, University of Milan, Via F. Sforza 35, 20122 Milan, Italy

Abstract


Heart failure is a chronic disease with high morbidity and mortality, which represents a growing challenge in medicine. A major risk factor for heart failure with reduced ejection fraction is a history of myocardial infarction. The expansion of a large infarct scar and subsequent regional ventricular dilatation can cause postinfarct remodelling, leading to significant enlargement of the left ventricular chamber. It has a negative prognostic value, because it precedes the clinical manifestations of heart failure. The characteristics of the infarcted myocardium predicting postinfarct remodelling can be studied with cardiac magnetic resonance and experimental imaging modalities such as diffusion tensor imaging can identify the changes in the architecture of myocardial fibers. This review discusses all the aspects related to postinfarct left ventricular remodelling: definition, pathogenesis, diagnosis, consequences, and available therapies, together with experimental interventions that show promising results against postinfarct remodelling and heart failure.