Open Access Open Access  Restricted Access Subscription Access

Atrial Fibrillation under Sub Arachnoid Block:Is Hydrogen Peroxide Irrigation the Culprit?


Affiliations
1 Department of Anaesthesia and Critical Care, King Georges Medical University, Lucknow, India
 

A 67 year old man posted for wound debridement of septic arthritis of the left hip developed atrial fibrillation after hydrogen peroxide irrigation during spinal anesthesia. Hydrogen peroxide is known to cause oxidative stress and air emboli leading to cardiac arrest. It has also been seen to affect action potential of cardiac myocytes in guinea pigs, but studies in humans are lacking. Exact cause of this event could not be elicited but hydrogen peroxide as a causative agent could not be ruled out either.

Keywords

Atrial Fibrillation, Hydrogen Peroxide, Subarachnoid Block.
User
Notifications
Font Size

  • Lu M, Hansen EN. Hydrogen Peroxide Wound Irrigation in Orthopaedic Surgery. J Bone Joint Infect. 2017; 2(1):3–9. https://doi.org/10.7150/ jbji.16690 PMid:28529858 PMCid:PMC5423573.
  • Timperley AJ, Bracey DJ. Cardiac arrest following the use of hydrogen peroxide during arthroplasty. The Journal of arthroplasty. 1989; 4(4):369–70. https://doi.org/10.1016/S0883-5403(89)80039-7.
  • Hayashi H, Miyata H, Watanabe H, Kobayashi A, Yamazaki N. Effects of hydrogen peroxide on action potentials and intracellular Ca2 concentration of guinea pig heart. Cardiovascular Research. 1989 ; 23(9):767– 73. https://doi.org/10.1093/cvr/23.9.767 PMid:2611815.
  • Neff SPW, Zulueta L, Miller R. Hydrogen peroxide: an unusual cause of arterial and venous gas embolism. Anaesthesia. 1996; 51(11):683–4. https://doi.org/10.1111/j.1365-2044.1996.tb04654.x PMid:8758164.
  • Beattie C, Harry L, Hamilton S, Burke D. Cardiac arrest following hydrogen peroxide irrigation of a breast wound. Journal of Plastic, Reconstructive and Aesthetic Surgery. 2010; 63(3). https://doi.org/10.1016/j.bjps.2009.07.012 PMid:19632911.
  • Spiriev T, Prabhakar H, Sandu N, Tzekov C, Kondoff S, Laleva L, et al. Use of hydrogen peroxide in neurosurgery: Case series of cardiovascular complications. JRSM Short Reports. 2012; 3(1):1–6. https:// doi.org/10.1258/shorts.2011.011094 PMid:22299072 PMCid:PMC3269103.
  • Youngs PJ. Arrhythmias during spinal anesthesia. Canadian Journal of Anesthesia/Journal canadien d’anesthésie. 2000; 47(5):385. https://doi.org/10.1007/BF03018964.

Abstract Views: 272

PDF Views: 78




  • Atrial Fibrillation under Sub Arachnoid Block:Is Hydrogen Peroxide Irrigation the Culprit?

Abstract Views: 272  |  PDF Views: 78

Authors

Priyal Gupta
Department of Anaesthesia and Critical Care, King Georges Medical University, Lucknow, India
Tanmay Tiwari
Department of Anaesthesia and Critical Care, King Georges Medical University, Lucknow, India

Abstract


A 67 year old man posted for wound debridement of septic arthritis of the left hip developed atrial fibrillation after hydrogen peroxide irrigation during spinal anesthesia. Hydrogen peroxide is known to cause oxidative stress and air emboli leading to cardiac arrest. It has also been seen to affect action potential of cardiac myocytes in guinea pigs, but studies in humans are lacking. Exact cause of this event could not be elicited but hydrogen peroxide as a causative agent could not be ruled out either.

Keywords


Atrial Fibrillation, Hydrogen Peroxide, Subarachnoid Block.

References