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Evidence of Hepatitis B Virus Infection in Cancer and Noncancer Stem Cells Associated with Human Hepatocellular Carcinoma


Affiliations
1 Section of Hepatology, Department of Medicine, University of Manitoba,Winnipeg, MB, R3E 3P4, Canada
2 Department of Pathology, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada
 

Both the hepatitis B virus (HBV) and cancer stem cells (CSCs) have been independently implicated in the pathogenesis of hepatocellular carcinoma (HCC). To date, there have been no reports describing HBV infection within CSCs. In this report we describe HBV core (HBcAg) and HBx protein expression within CSCs associated with human HCC. HBV markers were also identified in nonmalignant stemcells present in adjacent nontumor tissue. These findings provide newinsights into the pathogenesis of HBV-induced HCC and are potentially relevant to the treatment of both HCC and chronic HBV.
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  • Evidence of Hepatitis B Virus Infection in Cancer and Noncancer Stem Cells Associated with Human Hepatocellular Carcinoma

Abstract Views: 96  |  PDF Views: 0

Authors

Gerald Y. Minuk
Section of Hepatology, Department of Medicine, University of Manitoba,Winnipeg, MB, R3E 3P4, Canada
Wendy Bautista
Section of Hepatology, Department of Medicine, University of Manitoba,Winnipeg, MB, R3E 3P4, Canada
Julianne Klein
Department of Pathology, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada

Abstract


Both the hepatitis B virus (HBV) and cancer stem cells (CSCs) have been independently implicated in the pathogenesis of hepatocellular carcinoma (HCC). To date, there have been no reports describing HBV infection within CSCs. In this report we describe HBV core (HBcAg) and HBx protein expression within CSCs associated with human HCC. HBV markers were also identified in nonmalignant stemcells present in adjacent nontumor tissue. These findings provide newinsights into the pathogenesis of HBV-induced HCC and are potentially relevant to the treatment of both HCC and chronic HBV.