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Dexmedetomidine versus Magnesium Sulfate as Adjunct during Anesthesia for Laparoscopic Colectomy
Objectives: To compare dexmedetomidine versusmagnesium during laparoscopic colectomy. Patients and Methods: 51 patients were randomly allocated into 3 groups: groupC(control) received saline infusion, groupDdexmedetomidine 1 g/kg and then 0.4 g/kg/hr, and group MMgSO4 2 g and then 15 g/kg/min. Intraoperative hemodynamics weremeasured before and 1 min after intubation (T1 and T2), before and 5 min after peritoneal insufflation (T3 and T4), before and 5 min after 30° Trendelenburg position (T5 and T6), 5 min after resuming flat position (T7), 5 min after peritoneal deflations (T8), after extubation (T9), and at time of admission to PACU (T10). Recovery time and degree of sedation were assessed. Results: HR and MAP were significantly higher in T2, T4, and T6 compared to T1, T3, and T5, respectively, in all groups with lower measurements in groups D and M compared to group C. Mean of collective measurements was significantly higher in group C. Recovery time and sedation score were significantly higher in groups D and M. Time to Aldrete score of ≥9 was significantly longer in groups D and M. Conclusion: Both drugs ameliorate the pressor responses during LC with a nonsignificant difference.This study is registered with PACTR201602001481308.
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