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Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update


Affiliations
1 Institute of Molecular Biology and Biotechnology (IMBB),The University of Lahore, Pakistan
2 Center for Research in Molecular Medicine (CRiMM),The University of Lahore, Pakistan
3 University College of Medicine and Dentistry,The University of Lahore, Pakistan
4 Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia
 

Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomicDNAcells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is givenmostly in combination with other chemo/radiotherapies.We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds.
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  • Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update

Abstract Views: 152  |  PDF Views: 36

Authors

Arif Malik
Institute of Molecular Biology and Biotechnology (IMBB),The University of Lahore, Pakistan
Misbah Sultana
Institute of Molecular Biology and Biotechnology (IMBB),The University of Lahore, Pakistan
Aamer Qazi
Center for Research in Molecular Medicine (CRiMM),The University of Lahore, Pakistan
Mahmood Husain Qazi
Center for Research in Molecular Medicine (CRiMM),The University of Lahore, Pakistan
Gulshan Parveen
Institute of Molecular Biology and Biotechnology (IMBB),The University of Lahore, Pakistan
Sulayman Waquar
Institute of Molecular Biology and Biotechnology (IMBB),The University of Lahore, Pakistan
Abdul Basit Ashraf
University College of Medicine and Dentistry,The University of Lahore, Pakistan
Mahmood Rasool
Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia

Abstract


Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomicDNAcells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is givenmostly in combination with other chemo/radiotherapies.We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds.