Journal of Pure and Applied Ultrasonics

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Ultrasonic and Spectroscopic Study of Risperidone and Polyethylene Glycol Suspension


Affiliations
1 Acoustic Research Laboratory, Department of Physics, RTM Nagpur University, Nagpur - 440033, India
 

The ultrasonic absorption of drug-polymer suspension was determined as a function of temperature using pulser receiver. The suspensions were made up of a 1:1, 1:2, 1:3, 1:4, 1:5 mixture by weight of drug resperidone and polyethylene glycol by using ultrasonic probe sonicator. Ultrasonic velocity, density, and viscosity have been measured for different suspension at different temperature ranging from 10°C to 50°C and the various acoustical data are evaluated. The product was further characterized by using techniques such as scanning electron microscopy (SEM), fourier transform infrared spectrocopy (FTIR), Ultraviolet absorption (UV). The SEM investigations exhibit that as we increase polymer ratio the drug molecules are uniformly coated with polymer which is useful for stability and rate controlled drug release.

Keywords

Drug-Polymer Suspension, Ultrasonic, FTIR, SEM.
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  • Ultrasonic and Spectroscopic Study of Risperidone and Polyethylene Glycol Suspension

Abstract Views: 254  |  PDF Views: 3

Authors

Priti Kabra
Acoustic Research Laboratory, Department of Physics, RTM Nagpur University, Nagpur - 440033, India
O. P. Chimankar
Acoustic Research Laboratory, Department of Physics, RTM Nagpur University, Nagpur - 440033, India

Abstract


The ultrasonic absorption of drug-polymer suspension was determined as a function of temperature using pulser receiver. The suspensions were made up of a 1:1, 1:2, 1:3, 1:4, 1:5 mixture by weight of drug resperidone and polyethylene glycol by using ultrasonic probe sonicator. Ultrasonic velocity, density, and viscosity have been measured for different suspension at different temperature ranging from 10°C to 50°C and the various acoustical data are evaluated. The product was further characterized by using techniques such as scanning electron microscopy (SEM), fourier transform infrared spectrocopy (FTIR), Ultraviolet absorption (UV). The SEM investigations exhibit that as we increase polymer ratio the drug molecules are uniformly coated with polymer which is useful for stability and rate controlled drug release.

Keywords


Drug-Polymer Suspension, Ultrasonic, FTIR, SEM.

References