Open Access Open Access  Restricted Access Subscription Access

Ultrasonic and Spectroscopic Study of Risperidone and Polyethylene Glycol Suspension


Affiliations
1 Acoustic Research Laboratory, Department of Physics, RTM Nagpur University, Nagpur - 440033, India
 

The ultrasonic absorption of drug-polymer suspension was determined as a function of temperature using pulser receiver. The suspensions were made up of a 1:1, 1:2, 1:3, 1:4, 1:5 mixture by weight of drug resperidone and polyethylene glycol by using ultrasonic probe sonicator. Ultrasonic velocity, density, and viscosity have been measured for different suspension at different temperature ranging from 10°C to 50°C and the various acoustical data are evaluated. The product was further characterized by using techniques such as scanning electron microscopy (SEM), fourier transform infrared spectrocopy (FTIR), Ultraviolet absorption (UV). The SEM investigations exhibit that as we increase polymer ratio the drug molecules are uniformly coated with polymer which is useful for stability and rate controlled drug release.

Keywords

Drug-Polymer Suspension, Ultrasonic, FTIR, SEM.
User
Notifications
Font Size

  • British Pharmacopoeia, Ph. Eur. monograph 1559, Medicines and Health Care Products Regulatory Agency (MHRA), London, II (2013) 1380.
  • European Pharmacopoeia, Council of Europe, Fifth Edition, V (2005) 2374-2376.
  • www.drugbank.ca/drugs/DB00734
  • Cowie J.M.G. and Arrighi V., Polymers: Chemistry and Physics of Modern Materials, 3rd edition, CRC Press, New York, (2008).
  • Blandamer M.J., Introduction to Chemical Ultrasonics, In: Physical Chemistry, Academic Press, New York, 28 (1973).
  • Patil R, Dabrase A. and Suryavanshi B.M., Study of acoustical & excess parameters of NN- dimethylacetamide and acetonitrile at 303.15 & 308.15 K; Vid. Int. Interdis. Res. J., 1 (2004) 21-26.
  • Lemoff A.S., Bush M.F., O'Brien J.T. and Williams E.R., Structures of lithiated lysine and structural analogues in the gas phase: effects of water and proton affinity on zwitterionic stability, J. Phys. Chem. A. 110 (2006) 8433-8442.
  • Chimankar O.P., Tabhane V.A. and Chaudhari V.N., Molecular size and intermolecular binding energy determination of methyl-metha acrylic resins, J. Pure Appl. Ultrason., 32 (2010) 1-8.
  • Chimankar O.P., Shriwas R. and Tabhane V.A., Ultrasonic absorption studies in aqueous ß-alanine and L glutamic acid (monosodium salt); Pelagia Res. Lib. Adv. Appl. Sci.Res., 1 (2010) 78-85.
  • Chimankar O.P., Shriwas R. Jajodia S. and Tabhane V.A., Ultrasonic absorption and relaxation studies in aqueous Arginine and methionine using PEO technique; Arch. Phys. Res. 1(4) (2010) 160-167.
  • Richardson E.G., Ultrasonic Physics, 2nd Edition, Brown A.E. (Editor), Elsevier, New York, (1962).
  • Tiwari S.A. and Rajagopalan S. On the use of Moelwyn-Hughes parameter to evaluate thermo acoustical parameters in perfluoro benzene, Acoust. Lett. 14 (1990) 92.
  • Singh D.P. and Upmanyu A. Acoustical investigations of molecular interaction in polymer solution of Pan/Clay nano composites and DMSO; J. Polym. Biopolym. Phys. Chem. 2 ( 2014) 73-77.
  • Deslandes N., Bellenger V., Jaffiol F. and Verdu J. Solubility parameter of a polyester composite material; J. Appl. Polym. Sci. 169 (1998) 2663-2671.
  • Cho B. Volume dependence of isothermal bulk modulus of polymers; J. Appl. Phys. 67 (1990) 1320.

Abstract Views: 10

PDF Views: 1




  • Ultrasonic and Spectroscopic Study of Risperidone and Polyethylene Glycol Suspension

Abstract Views: 10  |  PDF Views: 1

Authors

Priti Kabra
Acoustic Research Laboratory, Department of Physics, RTM Nagpur University, Nagpur - 440033, India
O. P. Chimankar
Acoustic Research Laboratory, Department of Physics, RTM Nagpur University, Nagpur - 440033, India

Abstract


The ultrasonic absorption of drug-polymer suspension was determined as a function of temperature using pulser receiver. The suspensions were made up of a 1:1, 1:2, 1:3, 1:4, 1:5 mixture by weight of drug resperidone and polyethylene glycol by using ultrasonic probe sonicator. Ultrasonic velocity, density, and viscosity have been measured for different suspension at different temperature ranging from 10°C to 50°C and the various acoustical data are evaluated. The product was further characterized by using techniques such as scanning electron microscopy (SEM), fourier transform infrared spectrocopy (FTIR), Ultraviolet absorption (UV). The SEM investigations exhibit that as we increase polymer ratio the drug molecules are uniformly coated with polymer which is useful for stability and rate controlled drug release.

Keywords


Drug-Polymer Suspension, Ultrasonic, FTIR, SEM.

References