Study of Substituted 3,5-Diaryl Isoxazolines Complexes in 70% Dioxane Solvent Media pH-Metrically

Isoxazolines posses numerous medicinal activities. In present study complex formation between Pr(III)&Sm(III) metal ions and 3-(2-hydroxy-3-nitro-5-methylphenyl)-5-(2-phenylethenyl)isoxazoline[HNMP2EI]L₁,3-(2-hydroxy-3-nitro-5-methylphenyl)-5-(phenyl)isoxazoline [HNMP5PI]L₂,3-(2-hydroxy-3-bromo-4-nitro-5-methyl)-5-(3-nitrophenyl)isoxazoline[HBNM3NI]L₃ have been studied at 0.1M Ionic Strength (26±0.1)°C in 70% Dioxane water mixture by Bjerrum method as adopted by Calvin&Wilson. It is observed that Pr(III)&Sm(III) metal ions form 1:1&1:2 complexes with ligand L₁,L₂&L₃. The data obtained were used to estimate&compare the values of proton ligand stability constant (p^K) & metal ligand stability constant (log K). From estimated data (p^K&log K), the effect of substituents were studied.