Oxidative Stress Induced Apoptosis by Thiazolidine Compounds: A Unique Antifilarial Approach

The huge disability burden and its great socioeconomic impact has made research on antifilarial therapeutics to be essential. Mechanistic validation of antifilarial activity of already screened thiazolidine compounds showed statistically significant level of oxidative stress in terms of lower GSH and higher carbonyl content of protein in lysates of drug treated human lymphatic filarial parasites as opposed to those of untreated control. Evidence of apoptosis similar to positive control was also recorded in drug treated but not in the untreated control parasites. Therefore, it might be concluded that oxidative stress mediated apoptosis can be considered as a novel strategy for development of antifilarial therapeutics. Thiazolidine derivative is an important antifilarial lead with unique therapeutic rationale.