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Alteration of Leptin and C-Peptide Status in Homozygous Sickle Cell Anaemia


Affiliations
1 Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria
2 Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State, Nigeria
3 Department of Chemicalpathology, College of Medicine and Health Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
4 Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
5 Department of Human Anatomy, Imo State University, Owerri, Imo State, Nigeria
 

The study was carried out to determine the level of leptin and C-peptide in sickle cell anemia. Thirty confirmed sickle cell patients in steady state(HbSS-SS) and thirty normal haemoglobin (HbAA) as well as sixteen sickle cell disease in crises(HbSS-cr) between the ages of 15 to 30 years were selected in this study. Leptin and C-peptide were measured by commercially available ELISA kits. The results obtained showed that the levels of leptin and C-peptide in Sickle cell anaemia patients were significantly elevated when compared with HbAA subjects (P<0.05). However, the level of leptin and C-peptide in sickle cell steady state were highly significant when compared with those in crisis(P<0.05). This may probably implies that leptin and C-peptide decrease could enhance sickle cell crisis. Also, it could provide the understanding of the possible role of leptin and C-peptide in the pathophysiology of sickle cell anaemia.

Keywords

Leptin, C-Peptide , Sickle Cell Anaemia, Pathophysiology.
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  • Alteration of Leptin and C-Peptide Status in Homozygous Sickle Cell Anaemia

Abstract Views: 288  |  PDF Views: 126

Authors

Nnodim Johnkennedy
Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria
C. Meludu Samuel
Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State, Nigeria
C. E. Dioka
Department of Chemicalpathology, College of Medicine and Health Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Martin Ifeanyichukwu
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
Okorie Hope
Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria
G. C. Uloneme
Department of Human Anatomy, Imo State University, Owerri, Imo State, Nigeria

Abstract


The study was carried out to determine the level of leptin and C-peptide in sickle cell anemia. Thirty confirmed sickle cell patients in steady state(HbSS-SS) and thirty normal haemoglobin (HbAA) as well as sixteen sickle cell disease in crises(HbSS-cr) between the ages of 15 to 30 years were selected in this study. Leptin and C-peptide were measured by commercially available ELISA kits. The results obtained showed that the levels of leptin and C-peptide in Sickle cell anaemia patients were significantly elevated when compared with HbAA subjects (P<0.05). However, the level of leptin and C-peptide in sickle cell steady state were highly significant when compared with those in crisis(P<0.05). This may probably implies that leptin and C-peptide decrease could enhance sickle cell crisis. Also, it could provide the understanding of the possible role of leptin and C-peptide in the pathophysiology of sickle cell anaemia.

Keywords


Leptin, C-Peptide , Sickle Cell Anaemia, Pathophysiology.