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Assessing the Cytotoxic Effects of the Anti-HIV Drug, Garani MW1


Affiliations
1 Department of Medical Laboratory Sciences, College of Medicine, P.O. Box 360, Blantyre 3, Malawi
2 Department of Basic Medical Sciences, Division of Physiology, College of Medicine, P.O. Box 360, Blantyre 3, Malawi
 

The use of herbal medicine for the cure of HIV and AIDS is reported to be on the rise. Most of these herbal medicines have not been subjected to rigorous clinical testing and thus are considered unsafe within the medical establishment. The objective of the present study was to assess the cytotoxic potential of Garani MW1 aqueous extract using the brine shrimp assay. Brine shrimp larvae were incubated in Garani MW1 aqueous solution of 0, 100, 400, 600, 800, and 1000μL v/v for 12 and 24 hours. It was observed that Garani MW1 aqueous solution killed brine shrimps larvae in a dose and time dependent manner. Our results indicate that the herbal concoction has cytotoxic effects at higher concentrations of above 400μL v/v.

Keywords

Brine Shrimp, Cytotoxicity, Herbal Medicine, Garani MW1.
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  • Assessing the Cytotoxic Effects of the Anti-HIV Drug, Garani MW1

Abstract Views: 206  |  PDF Views: 102

Authors

James Jere
Department of Medical Laboratory Sciences, College of Medicine, P.O. Box 360, Blantyre 3, Malawi
Elizabeth Chimbayo
Department of Medical Laboratory Sciences, College of Medicine, P.O. Box 360, Blantyre 3, Malawi
Phillip Maiden
Department of Medical Laboratory Sciences, College of Medicine, P.O. Box 360, Blantyre 3, Malawi
Elizabeth Kampira
Department of Medical Laboratory Sciences, College of Medicine, P.O. Box 360, Blantyre 3, Malawi
Fanuel Lampiao
Department of Basic Medical Sciences, Division of Physiology, College of Medicine, P.O. Box 360, Blantyre 3, Malawi

Abstract


The use of herbal medicine for the cure of HIV and AIDS is reported to be on the rise. Most of these herbal medicines have not been subjected to rigorous clinical testing and thus are considered unsafe within the medical establishment. The objective of the present study was to assess the cytotoxic potential of Garani MW1 aqueous extract using the brine shrimp assay. Brine shrimp larvae were incubated in Garani MW1 aqueous solution of 0, 100, 400, 600, 800, and 1000μL v/v for 12 and 24 hours. It was observed that Garani MW1 aqueous solution killed brine shrimps larvae in a dose and time dependent manner. Our results indicate that the herbal concoction has cytotoxic effects at higher concentrations of above 400μL v/v.

Keywords


Brine Shrimp, Cytotoxicity, Herbal Medicine, Garani MW1.