SMU Medical Journal

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Long term use of antiretroviral therapy suppresses HIV infection in real. But due to mutation there is chance of drug resistance, drug toxicity, drug penetration, adherence to therapy, viral replication in cellular reservoirs and augmentation of host immune responses. Viral replication causes the accumulation of drug resistance, mutations, increase in viral loads and disease progression. The optimization of antiviral therapy by the understanding of the pathogenesis of drug resistant HIV-1 is essential. In the present review outlines various problems to HIV therapy and discussions about the success of antiviral therapy.

Keywords

Replication, Drug Resistance, Antiviral Therapy, Progression.
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