Problems and Proceedings to Antiretroviral Therapy for the Treatment of AIDS

Chinmaya Keshari Sahoo; Surepalli Ram Mohan Rao; Muvvala Sudhakar

Problems and Proceedings to Antiretroviral Therapy for the Treatment of AIDS

Chinmaya Keshari Sahoo ¹, Surepalli Ram Mohan Rao ², Muvvala Sudhakar ³

Affiliations
1 Department of Pharmaceutics, Osmania University College of Technology, Osmania University, Hyderabad, Telangana, India
2 Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, India

Abstract
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Long term use of antiretroviral therapy suppresses HIV infection in real. But due to mutation there is chance of drug resistance, drug toxicity, drug penetration, adherence to therapy, viral replication in cellular reservoirs and augmentation of host immune responses. Viral replication causes the accumulation of drug resistance, mutations, increase in viral loads and disease progression. The optimization of antiviral therapy by the understanding of the pathogenesis of drug resistant HIV-1 is essential. In the present review outlines various problems to HIV therapy and discussions about the success of antiviral therapy.