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Does Loss of LEKTI Expression Correlate with Increased Perineural Invasion in Squamous Cell Carcinoma of the Skin?


Affiliations
1 Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
2 Department of Medicine, Section of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, India
3 The American University of Antigua, College of Medicine, Antigua and Barbuda, Antigua and Barbuda
4 Amity Institute of Integrative Sciences and Health, Amity University of Haryana, Gurgaon-122413, India
 

Perineural invasion (PNI) is a unique route of tumor metastasis that is strongly associated with poor prognosis in several solid malignancies including head and neck squamous cell carcinoma (HNSCC). Recently, we investigated the pattern of Lympho-Epithelial Kazal-Type-Inhibitor (LEKTI) expression in primary tumor specimens of patients with SCC of the oral tongue in correlation with PNI and showed a strong association between absence of LEKTI expression and occurrence of PNI. Based upon the negative correlation of LEKTI expression with PNI in SCC of the tongue, we hypothesized that the same correlation may exist in SCC of the skin. Here, we selected a total of 11 cases with PNI and 15 cases without PNI. Our analyses showed a strong correlation between LEKTI expression and PNI in SCC of the skin and suggested that LEKTI might also be one of the critical molecules involved in the regulation of PNI of neuroendocrine cancers including of HNSCC.

Keywords

LEKTI, Perineural Invasion, HNSCC.
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  • Does Loss of LEKTI Expression Correlate with Increased Perineural Invasion in Squamous Cell Carcinoma of the Skin?

Abstract Views: 223  |  PDF Views: 123

Authors

Thomas Shellenberger
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Mitchell J. Frederick
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Ying Henderson
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Yaan Kang
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Karthik Jayakumar
Department of Medicine, Section of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, India
Vikram Vijayarajan
The American University of Antigua, College of Medicine, Antigua and Barbuda, Antigua and Barbuda
Gary L. Clayman
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Rajendra Prasad
Amity Institute of Integrative Sciences and Health, Amity University of Haryana, Gurgaon-122413, India
Arumugam Jayakumar
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States

Abstract


Perineural invasion (PNI) is a unique route of tumor metastasis that is strongly associated with poor prognosis in several solid malignancies including head and neck squamous cell carcinoma (HNSCC). Recently, we investigated the pattern of Lympho-Epithelial Kazal-Type-Inhibitor (LEKTI) expression in primary tumor specimens of patients with SCC of the oral tongue in correlation with PNI and showed a strong association between absence of LEKTI expression and occurrence of PNI. Based upon the negative correlation of LEKTI expression with PNI in SCC of the tongue, we hypothesized that the same correlation may exist in SCC of the skin. Here, we selected a total of 11 cases with PNI and 15 cases without PNI. Our analyses showed a strong correlation between LEKTI expression and PNI in SCC of the skin and suggested that LEKTI might also be one of the critical molecules involved in the regulation of PNI of neuroendocrine cancers including of HNSCC.

Keywords


LEKTI, Perineural Invasion, HNSCC.