Research Journal of Topical and Cosmetic Sciences

Swarnlata Saraf ¹, Sunil M. Hargude ¹, Chanchal Deep Kaur ¹, Shailendra Saraf ¹

Affiliations
1 University Institute of pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) – 492010, IN

Abstract

Allium sativum, family Alliaceae possessess antixidant, antimicrobial, antitumour, antimutagenic, antiinflammatory, antiviral and antiulcer properties. The aim of this study was to take the benefit of the nature of A. sativum extract and prepare shampoo incorporating in the herbal constituent base and evaluate this natural herbal shampoo. The herbal shampoo formulations comprising of aqueous extract of Allium sativum (5% to 30% w/w), coconut oil, castor oil, olive oil, fragrance were prepared and evaluated for physicochemical parameters and the results showed the production of stable herbal shampoos. The pH (6.22 ± 0.01 to 5.01± 0.02), percentage of solids (23.21± 0.02 to 25.41± 0.04), , dirt dispersion, surface tension (37.25 ± 0.45 to 39.87 ± 0.15), viscosity (6.5±0.2 to 5.4±0.2 ), skin irritation test ( no irritation) and visual stability .Formulations were clear, had good foam formation, foam quality and retention with proper rheological properties and skin compliances. The formulations with 10 % extract showed best results of evaluation parameters. The efficacy was in the range 10 % extract containing shampoo (F2) >5 % extract containing shampoo (F1) > 20 % extract containing shampoo (F3)> 30 % extract containing shampoo (F4).

Keywords

Allium sativum, Antimicrobial Herbal Shampoo, Natural Compositions.

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Anshita Gupta ¹, Swarnlata Saraf ¹, Chanchal Deep Kaur ², Shailendra Saraf ¹

Affiliations
1 University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, IN
2 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Dist-Durg, C.G, IN

Abstract

Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.

Keywords

DHEA, Testosterone, Estrogen, Targeted Drug Delivery.

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