Research Journal of Topical and Cosmetic Sciences

Manmohan S. Jangdey ¹, Anshita Gupta ¹, Abhishek K. Sah ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN

Abstract

In this study, to formulate Sustained Release Topical Gel of Flurbiprofen were all the prepared topical gel formulations contain different drug: polymer ratio using tamarind gum for long term therapy of rheumatoid arthritis. Flurbiprofen is a second generation non-steroidal anti-inflammatory agent, which is widely used in alleviating pain and inflammation. But its short half-life (only 3-4 hr), so its causes more fluctuation. After oral administration Flurbiprofen causes to produces heart burn, nausea, loose motions, pruritus, etc. The present study based on the preparation of bioadhesive topical gel of Flurbiprofen, so as to avoid all gastric side effects. For the preparation of bioadhesive topical gel natural polymer Tamarindus indica(plant Tamarind) was used. Bioadhesive polymers are the agents which increases the contact between the formulation and biological membrane, so as to avoid the fluctuation of formulation and behave as a sustained release formulation. In the present study, prepared bioadhesive topical gel was evaluated with the help of different parameters like drug content, spreadability, extrudability, swelling index study, in-vitro drug diffusion study. On the basis of in-vitro drug diffusion study measurement property of gel, we have concluded that natural polymer Tamarindus indica the best polymer for the preparation of sustained release bioadhesive topical gel.

Keywords

Topical Gel, Bioadhesion, Natural Polymer, Sustained Release.

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Anshita Gupta ¹, Swarnlata Saraf ¹, Chanchal Deep Kaur ², Shailendra Saraf ¹

Affiliations
1 University Institute of Pharmacy, Pt.Ravishankar Shukla University, Raipur, C.G, IN
2 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Dist-Durg, C.G, IN

Abstract

Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.

Keywords

DHEA, Testosterone, Estrogen, Targeted Drug Delivery.

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