Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Clinical Importance of Aloe Vera:Review


Affiliations
1 Surgycare Lifescience, Sendhwa (MP), India
2 SND College of Pharmacy, Yeola (MS), India
     

   Subscribe/Renew Journal


John Goodyew translated first reference from term ‘Dioscorides Medical treatise De Materia Medica’ into English terminology as use of Aloe vera in A.D. 1655; moreover, in early 1800s it used as laxative whereas in the mid 1930s successful treatment was introduced for chronic and severe radiation dermatitis. Since, several cultures of the history have been showed impression of foot print for use of Aloe vera, major includes Greece, Egypt, India, Mexico, Japan and China. Egyptian queens Nefertiti and Cleopatra regularly involved it in their beauty regimes whereas Alexander the Great, and Christopher Columbus used it to treat soldiers’ wounds. Aloe vera is well known plant not only in tribal community but modern lookout also make it therapeutic important. Since it is used in Ayurvedic, Homeopathic and Allopathic medicine because various research support that it contains vitamins, minerals, enzymes, amino acids, natural sugar and other bioactive compounds. Although therapeutic use of Aloe vera covered wide range of activity major includes emollient, purgative, antimicrobial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic, its benefits so myriad and astounding that no part in human body remains uninfluenced by its healing touch; all these make it plant of wonder. The modern therapeutic approach for beauty enhancer also list Aloe vera as most favorable plant in cosmetic industries. In this review we are trying to approach and underlying every possible corner associated with medicinal use of Aloe vera.

Keywords

Aloe vera, Wound Healing Agent, Antioxidant, Laxative, Anticancer, Anti Stress, Antidiabetic, Antidiabetic, Nutrient.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Davis, RH, Parker WL, Samson RT, and Murdoch DP. The isolation of an active inhibitory sytem from an extract of Aloe vera. J. Am Podiatr Med Assoc 81; 1991: 258-261.
  • Lopez, H, Camberros LO, and Ocampo AA. Comparative evaluation of a mixture of propolis and Aloe vera with commercial wound healing products. Veterinaria 20(4); 1989:407-414.
  • Tyler V. The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies, Third Edition. Pharmaceutical Products Press, Binghamton, NY. 1993.
  • Grindlay D, Reynolds T. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J ethnopharmacology. 16(1); 1986:117–15.
  • Foster S, et al. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. Haworth Herbal Press, New York. 1999.
  • Davis RH. Aloe vera: A scientific approach. Vantage Press, New York. 2000.
  • Brusick D, Mengs U. Assessment of the genotoxic risk from laxative senna products. Environmental and Molecular Mutagenesis 29(1); 1999:1-9.
  • Okamura N, Asai M, Hine H, and Yagi A. J. Chromatography.746(1); 1996: 225-233.
  • Jyotsana M, Sharma AK, Inamdar N, Harwinder Singh R and Ramnik S. Immunomodulatory properties of Aloe veragel in mice. Int J Green Pharmacy. 2(1);2008: 152-154.
  • Davis RH, Leitner MG, Russo JM and Byrne ME. Wound healing. Oral and topical activity of Aloe vera. J American Paediatric Medical Association. 79(1); 1989: 559-562.
  • Satish S, Raveesha KA and Janardhana GR. Antibacterial activity of plant extracts on phytopathogenic Xanthomonas campestris pathovars. Letters in Applied Microbiology 28; 1999; 145-147.
  • Zhang L and Tizard IR. Activation of mouse macrophage cell line by Acemannan; the major carbohydrate fraction of Aloe vera L. Immunopharmacology 35; 1996: 119-28.
  • Vogler BK and Ernst E. Aloe vera: A systematic review of its clinical effectiveness. The British journal of general practice: J Royal College of General Practitioners 49; 1999:823-828.
  • King GK, Yates KM and Greenlee PG. The effect of acemannan immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas. J American Animal Hospital Association 31; 1995: 439 -447.
  • Dagne E, Bisrat D, Viljoen A and Van Wyk BE. Chemistry of Aloe species. J Current Organic Chemistry 4; 2000: 1055-1078.,
  • Ombrello T. Aloe vera . http://faculty.ucc.edu/biology - ombrello /POW /Aloe_ vera. htm 2008, Accessed 2008/06/08.
  • Nassiff HA and Fajardo F, Velez F. Effect of aloe AS hiperlipidemia. Rev Cuba Med Gen Integr.9; 1993: 43-51.
  • Reddy Uma CH, Reddy SK and Reddy J. Aloe vera - A wound healer. Asian Journal of Oral Health and Allied Sciences 1; 2011: 91 -92.
  • Shamim S, Ahmed S, Waseemuddin and Azhar I. Anti fungal activity of Allium, Aloe, and Solanum species. Pharmaceutical Biology 42; 2004:491-498.
  • Ferro VA, Bradbury F, Cameron P, Shakir E, Rahman SR and Stimson WH. In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller. Antimicrobial agents and chemotherapy 47; 2003: 1137-1139.
  • D Jasso de Rodriguez, Hernandez Castillo D, Rodriguez Garcia R and Angulo-Sanchez J L. Antifungal activity in vitro of Aloe vera pulp and liquid fraction against plant pathogenic fungi. Industrial Crops and Products. 21; 2005: 81-87.
  • Hashemi SA, Madani SA, Saied A. The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds. BioMed Research International. 2015(1); 2015:1-7
  • Heggie S, et al. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs. 25(6); 2002:442-51.
  • Williams M, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys. 36(2); 1996:345-349.
  • Ganapathy N, Venkataraman SS, Daniel R. Molecular biology of wound healing. Journal of Pharmacy and Bioallied Sciences, vol. 4(6); 2012, 334-337.
  • Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem. 181; 1998:71-76.
  • Fulton JE Jr. The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. J Dermatol Surg Oncol. 16; 1990:460-467.
  • Mantle D, Gok MA, Lennard TW. Adverse and beneficial effects of plant extracts on skin and skin disorders. Adverse Drug React Toxicol Rev. 20(2); 2001:89-103.
  • Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing. Oral and topical activity of aloe vera. Journal of the American Podiatric Medical Association 79; 1989:559-562.
  • Newton LE . In defence of the name Aloe vera. The cactus and succulent journal of Great Britain. 41; 1979:29-30.
  • Heggers JP, Pelley RP, Robson MC. Beneficial effects of Aloe in wound healing. Phytotherapy research. 7; 1993:S48–S52.
  • Shelton RM. Aloe vera, its chemical and therapeutic properties. International journal of dermatology. 30; 1991:679-683.
  • Davis, RH, et al. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Journal of the American Podiatric Medical Association. 84(2); 1994: 77-81.
  • Tizard AU et al. Effects of acemannan, a complex carbohydrate, on wound healing in young and aged rats. Wounds, a compendium of clinical research and practice 6; 1995:201-209.
  • Roberts DB, Travis EL. Acemannan-containing wound dressing gels reduce radiation-induced skin reactions in C3H mice. International journal of radiation oncology, biology and physiology 15; 1995:1047-1052.
  • Saroj PL, D handar DG and Singh RS. Indian Aloe. Central Institute for Arid Horticulture, Bikaner 2004: 6-10.
  • Mortan JF. Folk uses and commercial exploitation of Aloe veraleaf pulp. Economic Botany15; 1961:311-319.
  • Femenia A, Sanchez ES, Simal S and Rosello C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues.arbohydr. Polym.39; 1999: 109-117.
  • Sims P, Ruth M and Zimmerman ER. Effect of Aloe veraon Herpes simplex and herpes virus (strain Zoster). Aloe vera of Amer ican Archives 1;1971:239-240.
  • Stone N, Meistar A. Function of ascorbic in the conversion of proline to collagen hydroxyproline. Nature 194;1965: 555-57.
  • El-Shemy HA, Aboul-Soud MA, Nassr-Allah AA, Aboul-Enein KM, Kabash A and Yagi A. Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction. Current Organic Chemistry 17;2010: 129-138.
  • Kirtikar KR and Basu BD. Indian Medicinal Plants. Vol. IV (IIndEd.).Pub. Lalit Mohan Basu, Allahabad, India, 1989.
  • Davis HR. Aloe vera: A Scientific Approach Published by Vantage Press NewYork, SA. http://www.aloevera.co.uk/rhdavis.htm 1997, Accessed 2011/07/07.
  • Barcroft SL and Alasdair NT. Aloe vera Healer, (www .JoJaffa.com), http://www.AloeVeraHealer.com, 1999, Accessed 2011/03/09.,
  • Yates A. Yates Garden Guide. Harper Collins Australia 2002, pp.135-137.
  • Jones K and Aloe C. The anti-diabetic activity of Aloe vera. Cosmetic Science Technology 2; 2005: 34-35
  • Green P. Aloe vera extracts in equine clinical practice. Veterinary Times 26; 1996:9-12.'
  • Gordon MC and David JN. Natural product drug discovery in the next millennium. Pharm. Biology39; 2001: 8-17.
  • Mckeown E. Anthraquinones and anthracenic derivatives absorb UV light. Cosmetics and toiletries. 102; 1987:64-65.
  • Leigh GC. Dental irrigators. Research letters Br. Dent. Journal 198; 2005: 756-763.
  • Kaufman T, Kalderon N, Ullmann Y, et al. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study.J Burn Care Rehabil. 9; 1988:156-159.
  • Crowell J, Penneys N. The effects of aloe vera on cutaneous erythema and blood flow following ultraviolet B (UVB) exposure. Clin Res. 35; 1987:676A.
  • Syed TA, Cheema KM, Ashfaq A, et al. Aloe vera extract 0.5% in ahydrophilic cream versus Aloe vera gel for the management of genital herpes in males. A placebo-controlled, double-blind, comparative study [letter]. J Eur Acad Dermatol Venereol. 7;1996: 294-295.
  • Syed TA, Ahmad SA, Holt AH, et al. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study. Trop Med Int Health. 1; 1996:505-509.
  • Vardy DA, Cohen AD, Tchetov T, et al. A double-blind, placebo-controlled trial of an Aloe vera (A. barbadensis) emulsion in the treatment of seborrheic dermatitis. J Dermatol Treat. 10; 1999:7-11.
  • Udupa, SL, Udupa AL and Kulkarni DR. Anti-inflammatory and wound healing properties of Aloe vera. Fitoterapia. 65(2); 1994: 141-145.,
  • Davis, RH et al. Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. Journal of the American Podiatric Medical Association. 84(12); 1994: 614-21.
  • Tucker AO, Duke JA, Foster S. Botanical nomenclature of medicinal plants. In: Cracker LE, Simon JE, eds. Herbs, spices and medicinal plants, Vol. 4. Phoenix, AR, Oryx Press, 1989:169–242.
  • Robson MC, Heggers J, Hagstrom WJ. Aloe vera revisited. Journal of burn care and rehabilitation, 3; 1982:157-162.
  • Udupa, SL, Udupa AL and Kulkarni DR. Anti-inflammatory and wound healing properties of Aloe vera. Fitoterapia 65(2); 1994: 141-145.
  • Davis, RH, et al. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Journal of the American Podiatric Medical Association. 84(2); 1994: 77-81.
  • Lee KH, et al. Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne. J Pharm Pharmacol. 52(5); 2000:593-8.
  • Pulse, T. 1988. Whole leaf Aloe vera juice used in AIDS treatment. About Aloe vera. (obtained from defunct webpage).
  • Atherton Peter. Aloe vera Myth or Medicine? Positive Health Publications, www.positivehealth.com/permit/Articles/AloeVera/atherton.htm, Online, 2002, Accessed 2011/05/13.
  • Rodriguez DJ, Hernandez CD, Rodríguez GR and Angulo Sanchez JL. Antifungal activity in vitro of Aloe vera pulp and liquid fraction against plant pathogenic fungi. Industrial Crops and Products 21; 2005:81-87.
  • Lee JK, et al. Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int Immunopharmacol. 1(7); 2001:1275-84.
  • Pugh N, et al. Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 49(2); 2001:1030-4.
  • Reynolds T, Aloes: The Genus Aloe, CRC press, 2004.
  • Lee KH, et al. Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne. J Pharm Pharmacol. 52(5); 2000:593-8.
  • Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 35(2); 1996:119-28.
  • Furukawa F, et al. Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. Cancer Lett. 25;178(2); 2002:117-22.
  • Vogler BK and Ernst E. Aloe vera: A systematic review of its clinical effectiveness. The British journal of general practice: The journal of the Royal College of General Practitioners 49;1999, 823-828.
  • Yeh GY, et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 26(4); 2003: 1277-94.
  • Mantle D, Gok MA, Lennard TW. Adverse and beneficial effects of plant extracts on skin and skin disorders. Adverse Drug React Toxicol Rev. 20(2); 2001: 89-103.
  • Al Awadi F, Fatania H, Shamte U. The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diabetes Research 18; 1991:163-168.
  • Crowell J, Penneys N. The effects of aloe vera on cutaneous erythema and blood flow following ultraviolet B (UVB) exposure. Clin Res. 35; 1987:676-678.
  • Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem. 181; 1998:71-76.
  • Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 49(447); 1999:823-828.
  • Ghannam N, Kingston M, Al Meshaal IA, Tariq M, Parman NS, Woodhouse N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. Horm Res. 24(4); 1986:288-94.
  • Davis RH, Leitner MG, Russo JM and Byrne ME. Wound healing.Oral and topical activity of Aloe vera. Journal of the American Paediatric Medical Association 79; 1989: 559–562.
  • Cheesbrough M. Medical Laboratory Manual for Tropical Countries. Vol. II, first edition. Printed and bond in Great Britain by the university Press, Cambridge 1984, pp. 372-391.
  • Grindlay D and Reynadds T. The Aloe vera Phenomenon. A review of the properties and modern uses of the leaf parenchyma gel. J.Ethnopharmacol 16; 1986:117-151.
  • Neall B. Aloe’s new role in functional foods. Food Review 31; 2004: 24-25.
  • Anonymous. Water conservation. Chennai, India: The Hindu, India. 2008c, http://www.hindu.co/seta/2008/07/10/stories.2008071050161 800. htm . Accessed 2010/12/15.,
  • Nadkerni KM. Indian Meteria Medica Vol. I (3rd ed.). Pub. Bommbay Popular Prakashan Private Limited. 1976, pp. 73-74.
  • Joseph B and Justin Raj S. Pharmacognostic and phytochemical properties of Aloe vera Linn. - An overview. International Journal of Pharmaceutical Science Review and Research 2; 2010: 106-110.
  • Thomson PDR. Herbal Medicines, Third Edition, NJ: Thomson PDR. 2004, Pp.16-20.
  • Marshall J. Aloe vera gel: what is the evidence? Pharmaceutical Journal 244; 2000: 360-362.
  • Agarry OO, Olaleye MT and Bello-Michael CO. Comparative antimicrobial activities of Aloe vera gel and leaf. African Journal of Biotechnology 4; 2005: 1413-1414.
  • Langmead L, Makins RJ and Rampton DS. Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther. 19;2004b: 521-527.
  • Rabe T and Staden J Van. Antibacterial activity of South African plants used for medicinal purposes. Journal of Ethnopharmacology 56; 1997: 81-87.
  • Davis RH, Leitner MG, Russo JM and Byrne ME. Wound healing. Oral and topical activity of Aloe vera. Journal of the American Paediatric Medical Association 79;1989: 559-562.
  • Liao Z, Chen M, Tan F, Sunl X and Tang K. Microprogagation of endangered Chinese aloe Plant Cell, Tissue and Organ Culture 76;2004: 83-86.
  • Zhang L and Tizard IR. Activation of mouse macrophage cell line by Acemannan; the major carbohydrate fraction of Aloe vera L. Immunopharmacology 35; 1996: 119-28.
  • Nassiff HA and Fajardo F, Velez F. Effecto del aloe sobre la hiperlipidemia en pacientes refractarios a diet. Rev Cuba Med Gen Integr. 9;1993: 43-51.
  • Barcroft S L and Alasdair N T. Aloe vera Healer,(www.JoJaffa.com), http://www. AloeVeraHealer.com, 1999,Accessed 11/03/09.86.
  • Zhang L and Tizard IR. Activation of mouse macrophage cell line by Acemannan; the major carbohydrate fraction of Aloe vera L. Immunopharmacology 35; 1996: 119-28.
  • Rolf C and Zimmerli T. Experience Aloe vera is miraculous health supporting benefits. http://wholeleaf.com 2000, Accessed 2011/08/17.
  • Newall CA, Anderson LA and Phillipson JD. Herbal medicines. The pharmaceutical Press wilkensiana. Journal of Ethnopharmacology 25; 1996a: 215-220.
  • Tyler VE, Brady LR and Robbers JE. Pharmacognosy. Philadelphia: Lea and Febiger 2; 1976: 81-83.]
  • Anonymous. Taxon: Aloe vera (L) Burm. Germplasm Resources Information Network, United States Department of Agriculture 2008b, http://www.ars-grin.gov/cgibin/npgs/html/tax_search.pl?Aloe%20vera, Accessed 2011/08/27.
  • Tyler V. Herbs of Choice: The Therapeutic Use of Phytomedicinals. Binghamton, NY: Pharmaceutical Products Press; 1994. , Brusick D, Mengs U. Assessment of the genotoxic risk from laxative senna products. Environmental and Molecular Mutagenesis 29; 1997:1-9.
  • Foster S, et al. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. New York: Haworth Herbal Press; 1999.
  • Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 14(8); 2000:581-91.
  • Langmead L, et al. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther. 19(7); 2004:739-47.
  • Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 49(447); 1999:823-8.

Abstract Views: 486

PDF Views: 0




  • Clinical Importance of Aloe Vera:Review

Abstract Views: 486  |  PDF Views: 0

Authors

Akhilesh Gupta
Surgycare Lifescience, Sendhwa (MP), India
Swati Rawat
SND College of Pharmacy, Yeola (MS), India

Abstract


John Goodyew translated first reference from term ‘Dioscorides Medical treatise De Materia Medica’ into English terminology as use of Aloe vera in A.D. 1655; moreover, in early 1800s it used as laxative whereas in the mid 1930s successful treatment was introduced for chronic and severe radiation dermatitis. Since, several cultures of the history have been showed impression of foot print for use of Aloe vera, major includes Greece, Egypt, India, Mexico, Japan and China. Egyptian queens Nefertiti and Cleopatra regularly involved it in their beauty regimes whereas Alexander the Great, and Christopher Columbus used it to treat soldiers’ wounds. Aloe vera is well known plant not only in tribal community but modern lookout also make it therapeutic important. Since it is used in Ayurvedic, Homeopathic and Allopathic medicine because various research support that it contains vitamins, minerals, enzymes, amino acids, natural sugar and other bioactive compounds. Although therapeutic use of Aloe vera covered wide range of activity major includes emollient, purgative, antimicrobial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic, its benefits so myriad and astounding that no part in human body remains uninfluenced by its healing touch; all these make it plant of wonder. The modern therapeutic approach for beauty enhancer also list Aloe vera as most favorable plant in cosmetic industries. In this review we are trying to approach and underlying every possible corner associated with medicinal use of Aloe vera.

Keywords


Aloe vera, Wound Healing Agent, Antioxidant, Laxative, Anticancer, Anti Stress, Antidiabetic, Antidiabetic, Nutrient.

References