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In-vitro Biological Screening of Avicennia marina for Anticancer Activity
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Avicenniaceae family is a member of true mangrove plants which has one genus, 11 species and several subspecies. Avicennia marina is the most current species among these plants in many forests attracting many researchers for newer investigation. Regarding to the presence of many active biological constituents in this plant and their applications in traditional and alternative medicine, the in-vitro anticancer activity of its leaf extract on various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T) were determined by XTT bioassay. With use of XTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from XTT bioassay screening revealed that methanolic and aqueous extract of Avicennia marina shown cytotoxicity against HL-60 and NCI-H23 cell line with proficient IC50 values and shown insignificant toxicity against normal cell line (HEK-293T).
Keywords
Avicennia marina, XTT bioassay, anticancer activity, Avicenniacea
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- El-Ghonemy AA. Encyclopedia of Medicinal Plants of the United Arab Emirates. 1st Edition, University of U.A.E., 1993.
- Ghazanfar SA. Handbook of Arabian Medicinal Plants, CRC Press, 210, 1994.
- Jongbloed MV. The Comprehensive Guide to the Wild Flowers of the United Arab Emirates, Erwda, Emirates Printing Press, Dubai, U.A.E., 2003.
- Kotb TF. Medicinal Plants in Libya. Arab Encyclopedia House. Tripoli-Libya, 1985.
- Western AR. The Flora of United Arab Emirates, an introduction. Publication of the U.A.E University, 1986.
- Bandaranayake WM. Traditional and medicinal uses of mangroves. Mangroves and Salt Marshes, 1998, 2, 133-148.
- Bandaranayake WM. Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetland. Ecol. Manage, 2002, 10, 421-52.
- Tomlinson PB. The Botany of Mangroves. Cambridge University Press. New York, USA., 1994, 163-170.
- Miles DH, Kokpol U, Chittawong V, Tip-Pyang S, Tunsuwan K and Nguyen C. Mangrove forests-The importance of conservation as a bioresource for ecosystem diversity and utilization as a source of chemical constituents with potential medicinal and agricultural value. IUPAC, 1998, 70 (11), 1-9.
- Department of Biomedical Sciences, Zyed Complex for Herbal Research and Traditional Medicine, Unpublished results.
- Department of Pharmacognostic Sciences, Zyed Complex for Herbal Research and Traditional Medicine (ZCHRTM), unpublished results.
- Freshney IR. Culture of animal cells: a manual of basic technique, Wiley-Liss, New York (USA), 2005, pp. 5, 200-201, 209-211, 213-214, 251, 328-332, 335-338, 359-370, 508.
- Sukhramani PS, Sukhramani PS, Desai SA, Suthar MP. In-vitro cytotoxicity evaluation of novel N-substituted bisbenzimidazole derivatives for anti-lung and anti-breast cancer activity. Annals of Biological Research, 2011, 2 (1): 51-59.
- Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy, Nirali Prakashan, Pune, 36th Edition, 2006, pp. 593-597.
- Sukhramani PS, Desai SA, Suthar MP. In-Vitro Cytotoxicity screening of 2-(2, 3-dioxo-2, 3-dihydro-1H-indol-1-yl)-Nphenylacetamide derivatives for Anti-Lung and Anti-Breast cancer activity. Journal of Pharmacy Research, 2011, 4(1), 124- 127.
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