Research Journal of Pharmacognosy and Phytochemistry

S. Satish ¹, G. Sankara Aditya Sarma ¹, B. Ashok Reddy ¹, V. Sai Kishore ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla, Guntur Dist-522415, A.P., IN

Abstract

The influence of Soapnut on the permeability of Eudragit RL100 films was studied with a view to develop a suitable rate controlling membranes for transdermal use. Dibutyl phthalate was incorporated at a concentration of 15% w/w of dry polymer as plasticizer. The dry free films were evaluated for various mechanical properties further the permeability characteristics of free films was studied using propranalol hydrochloride and diltiazem hydrochloride as model drugs. Both water vapour transmission and drug diffusion rate followed zero order kinetics. The soapnut powder showed a significant influence on the mechanical as well as permeability characteristics. This may be due to difference in the affinity of soapnut with the film former. From this study it was concluded that the plasticized free films of Eudragit RL100 prepared with soapnut can be used as rate controlling membranes to develop transdermal drug delivery systems.

Keywords

Soapnut, Eudragit RL100, Dibutyl Phthalate, Permeability, Diffusion.

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P. Srujana ¹, V. Sai Kishore ¹, K. Srikanth ¹, P. Y. Shanmukha ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, IN

Abstract

Aloe vera is a perennial, drought-resisting, succulent plant belonging to the Liliaceae family which, historically has been used for a variety of medicinal purposes. It has a vast traditional role in indigenous system of medicine like ayurveda, siddha, unani and homoeopathy. As a result of its use as folk medicine, it is claimed that aloe vera has wound and burn healing properties, antifungal activity, hypoglycemic or antidiabetic effects anti-inflammatory, anticancer, immunomodulatory and gastroprotective properties. Aloe vera is used in a variety of commercial products because of these therapeutic properties. The known biological activities of A. vera were briefly discussed and also further highlighted recently discovered effects and applications of the leaf gel. The present review is therefore, an effort to give a detailed survey of the literature on its traditional, phytochemical and pharmacological properties, Industrial processing technique and Industrial uses. With technological developments in the field of analytical chemistry it has become easier to isolate and characterise the chemical components of the leaf gel and it is expected that more information in this regard will become available in the future at a faster rate. More applications are discovered as research from different viewpoints is conducted on this versatile plant to provide a better understanding of its composition and effects. Further research needs to be done to unravel the myth surrounding the biological activity and the exploitation of aloe constituents.

Keywords

Aloe Vera, Phytochemical, Pharmacological, Cosmetic, Pharmaceutical, Food Industries.

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