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Undale, V. R.
- Central Nervous System Depressant Activity of Ethanol Extract of Aerial Parts of Cynodon dactylon (L.) Pers. (Durva) in Mice
Authors
1 Department of Pharmacology, PDEA’S SGRS College of Pharmacy, Saswad, Tal-Purandar, Dist- Pune, Maharashtra, 412301, IN
2 Department of Pharmacology, PDEA’S SGRS College of Pharmacy, Saswad, Tal- Purandar, Dist- Pune, Maharashtra, 412301, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 2 (2009), Pagination: 119-122Abstract
Cynodon dactylon L. (Durva) a shrub from Poaceae family is popularly used in folk medicine for treating a wide variety of disorders in South and western India, China and central Asia. Aim of the study: To investigate the CNS depressant properties on experimental animals.
Materials and methods: ethanol extract of aerial parts of Cynodon dactylon (EECD) was studied to investigate its CNS depressant pharmacological properties in the classical behavioral models (openfield, elevated plus maze-EPM, Rota-rod, and Barbiturate-induced sleeping time) using mice. We decided to use i.p. administration of drugs because this pathway allows faster viability of the ethanol extract of aerial parts of Cynodon dactylon than oral pathway using 50% propylene glycol as a solvent in mice at single doses of 50, 75 and 100mg/kg.
Results: No significant effect was evident on motor coordination of the animals in the rotarod test. On EPM, all the doses of EECD presented a significant reduction on the time of permanence in the open arms, indicating an absence of anxiolytic-like effect. In addition, the EECD increased the immobility time in the forced swimming test and potentiated pentobarbital-induced sleeping time in mice, confirmed a probable sedative and central depressant effect in the animals.
Conclusion: Our results suggest that the ethanol extract of c. dactylon at 75mg/kg and 100mg/kg dose biologically active substance(s) that might be acting in the CNS and have significant depressant and anticonvulsant potentials, supporting folk medicine use of this plant.
Keywords
C. dactylon, Central Nervous System, EECD, EPM, FST.
- Evaluation of Anti-Inflammatory, Antipyretic and Wound Healing Activity of Curcuma Inodora (Zingibaraceae)
Authors
1 PDEA’s SGRS College of Pharmacy, Saswad, Tal- Purandar, Dist- Pune, Mharashtra-412301, IN
2 Department of Pharmacology, PDEA’s SGRS College of Pharmacy, Saswad, Tal- Purandar. Dist-Pune, Maharashtra, 412301, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 35-40Abstract
Curcuma inodora is small Zingibarous herb and is used by the tribal's as a hair tonic and for cure of wounds. The objective of the present investigation was to study the selected dose of dried methanol extract of rhizomes of Curcuma inodora (200mg/kg i.p.) toward possible antiinflammatory, antipyretic and wound healing potential in experimental animal models. Anti-inflammatory potential of methanol extract was evaluated by carrageenan induced paw oedema and formalin induced paw oedema in rats. Also antipyretic and wound healing activity was also tested on animal models. The studies were conducted on Wistar rats of either sex (160-180 g). The change in oedema volume of the rat hind paw was measured using plethysmometer. The dried methanol extract of curcuma inodora (L.) inhibited the formation of paw oedema to significant levels in rats treated either with carrageenan or formalin. At a dose of 200 mg/kg orally, the dried methanol extract produced 74% inhibition in case of the carrageenan-induced oedema (P<0.01), and there was 79.61% inhibition in formalin-induced oedema (P<0.01).
Dried methanol extract of Curcuma inodora was also evaluated for antipyretic activity on animals as per Vogel's method. Curcuma inodora elicited a dose dependant inhibition of rectal temperature compared with control group. Dried methanol extract of Curcuma inodora produced 38.31 % inhibition at 200 mg/kg dose with a maximal inhibition 44.06 % at same dose which was compared with standard inhibition at 100 mg/kg p.o.
In excision wound model, 10% ointment of ethanol extract of C. inodora was evaluated for wound healing activity. The result showed that ethanol extract ointment possesses a definite pro-healing action. This was demonstrated by a significant increase in the rate of wound contraction and by enhanced epithelialization.
The results indicated that the dried methanol extract of the rhizomes was active against all the experimentally induced laboratory models of inflammation, pyrexia and wound healing.