Research Journal of Pharmacognosy and Phytochemistry

S. B. Datir ¹, S. A. Nirmal ², A. B. Ganjare ², S. B. Bhawar ³, M. J. Patil ⁴

Affiliations
1 Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, A/P- Loni, Tal -Rahata, Dist- Ahmednagar, Pin- 413736, Maharashtra, IN
2 Dep. of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, IN
3 Dep. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, IN
4 Deparrment of Pharmacognosy, M.M. College of Pharmacy, Pune, IN

Abstract

Achyranthes aspera is common weed found in India and has great medicinal importance. The plant is beneficial in various ailments including stomachache, piles, boils, skin eruption and in asthma. It is also used as anti-inflammatory and as immunomodulator drug. It may act on reactive oxygen species which are one of the factor in the pathogenesis of these diseases. Various extracts of A. aspera, viz., petroleum ether extract, chloroform extract, ethyl acetate extract, ethanol extract and aqueous extract were screened for the antioxidant activity of the plant by using DPPH assay, ABTS assay and FRAP assay. Among all these extracts petroleum ether extract was found to be active as it shows lowest IC50 value in DPPH assay and highest trolox equivalent antioxidant concentration (TEAC) in ABTS assay and FRAP assay. Phytochemical screening revealed that as flavonoids, tannins and phenolic compound are absent in the plant, nonpolar compounds like steroids may be responsible for the antioxidant activity of the plant.

Keywords

Achyranthes aspera, DPPH Assay, ABTS Assay, FRAP Assay.

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S. A. Gangurde ¹, P. H. Jadhav ², S. M. Dange ², S. B. Datir ², N. P. Jain ³, S. C. Pal ⁴

Affiliations
1 Department of Pharmacognosy, S.N.D. College of Pharmacy, A/P-Babhulgaon, Tal - Yeola, Dist-Nashik, Pin-423401, Maharashtra, IN
2 Department of Pharmacognosy, S.N.D. College of Pharmacy, Yeola (M.S), IN
3 Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola (M.S), IN
4 Department of Pharmacognosy, N.D.M.V.Ps College of Pharmacy, Nasik (M.S), IN

Abstract

Soymida febrifuga belonging to family meliaceae is commonly called mans Rohini in Marathi and traditionally reported for treatment of various diseases. Different parts of S. febrifuga are reported in Ayurvedic medicine for treatment of variety of ailments like dysentery, cough, asthma and antiperiodic. Efforts will be made to find out active constituents and their pharmacological action. Traditionally plant was known to have activity against worms and have been used in the treatment of dysentery caused by worms. Thus the present study aims to evaluate the traditional anthelmintic properties of the plant. Aqueous extract and methanol extract of the wood of S. febrifuga were screened for anthelmintic activity. Results showed that methanol extract of the wood of S. febrifuga is having potent anthelmintic activity. Thus we can conclude that, the anthelmintic property of the plant is due to the polar phytoconstituents present in the wood.

Keywords

Soymida febrifuga, Anthelmintic Activity, Pherotima posthuma.

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