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Suthakaran, R.
- Phytochemical Screening and invivo Nootropic Evaluation of Carissa carandus linn. Roots
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Authors
Affiliations
1 Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
1 Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 2 (2016), Pagination: 81-84Abstract
The present investigation was planned with an objective to screen phytochemically andneuropharmacologically the ischolar_mains of Carissa carandus Linn.in rats. Carissa carandus Linn.(karaunda), common herb of dogbane family Apocynaceae. It has been used as additive in Indian pickles1. The extraction of Carissa carandus Linn. ischolar_mains was carried out by Soxhlet apparatus by successive solvent extraction in the order of increasing polarity with solvents such as hexane, methanol and water respectively for 24 hours. Phytochemical screening of the extracts reveals the presence of following chemical constituents such as carbohydrates, proteins, lignans, flavonoids, terpenes, saponins glycosides, cardiac glycosides etc. Nootropic activity was carried out with methanolic extract (200 mg/kg) in albino rats by using object recognition test. The rats of all the groups are placed one by one in an empty object recognition test chamber to get habituated to the environment for a period of 5 minutes before the test session. The rats were allowed to explore a familiar object (F) and a new object (F1) on first day test trail for a period of 5 minutes. Second day test trial includes exploration of a previous familiar (F) object and a new object (N). The result obtained indicate that discrimination index with control rats were found to be 0.0470±0.113 sec, whereas with test treated rats discrimination index was found to be 0.2042 ±0.412 sec. This increase in discrimination index with Carissa carandus Linn. methanolic ischolar_main extract treated rats in object recognition test suggests that Carissa carandus Linn. ischolar_mains posseses significant memory enhancing potential.Keywords
Carissa carandus Linn.Roots, Nootropic Activity, Object Recognition Test, Discrimination Index.- Pharmacognostical and Pharmacological Evaluation of the Polyherbal Extract on Rodents
Abstract Views :148 |
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Authors
A. Tamil Selvan
1,
R. Suthakaran
1,
B. Karun Kumar
1,
R. Naveen Kumar
1,
M. Naveena Mala
1,
D. Jai Ram
1,
M. Praveen
1
Affiliations
1 Department of Pharmacognosy, Teegala Ram Reddy College of Pharmacy, Meerpet, Saroor Nagar (M), Hyderabad, IN
1 Department of Pharmacognosy, Teegala Ram Reddy College of Pharmacy, Meerpet, Saroor Nagar (M), Hyderabad, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 6, No 2 (2014), Pagination: 80-83Abstract
Hyperlipedemic is the greatest risk factor for coronary heart diseases. It is characterized by elevated serum total cholesterol, low density lipoprotein, very low density lipoprotein and decreased high density lipoprotein levels. Methanolic extract of Terminalia arjuna (bark), Phyllanthus emblica (fruits), Withania somnifera (leaves), Convolvulus pluricaulis (whole plant), Piper betle (leaves), Allium sativum (bulb), Piper longum (dry fruits), Zingiber officinale (rhizomes), Tribulus terrestris (whole plant) and Cardamom (dry fruits) these herbs were tested against high cholesterol diet induced hyperlipedemic in adult albino rats. The therapeutic dose is calculated as 200mg/kg as per the toxicity guidelines OECD 423. Fenofibrate 65mg/kg is used as a standard drug. The methanolic extracts shows a significant decrease in the levels of serum cholesterol, Triglycerides, LDL, VLDL and significant increase in the level of serum HDL against high cholesterol diet induced hyperlipedemic rats. The results shows that the polyherbal extract possess significant (p<0.001) antihyperlipedemic activity suggesting the potential role in coronary artery disease and in hyperlipidemia.Keywords
Antioxidant, Polyherbs, Hyperlipidemia, High Cholesterol Diet, Methanolic Extract.- Evaluation of Analgesic Potential of Boerhavia diffusa Roots in Albino Mice
Abstract Views :227 |
PDF Views:5
Authors
Affiliations
1 Department of Pharmacology, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
2 Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
3 Department of Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
1 Department of Pharmacology, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
2 Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN
3 Department of Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munaganoor – 501511, Hyderabad, Telangana, IN