Research Journal of Pharmacognosy and Phytochemistry

M. K. Kale ¹, M. P. Patil ², K. P. Bhusari ³

Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur 441110, IN
2 Tapi Valley’s, College of Pharmacy, Faizpur, Ta. Yawal , Dist. Jalgaon (MS), IN
3 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441110, IN

Abstract

Nephrotoxicity is the major cause of morbidity and mortality in diabetes and it is the leading cause of end stage renal disease. Hyperglycemia induced oxygen free radicals cause oxidative stress and subsequent oxidative damages, leading cell and tissue injury. Sprague-Dawley rats of both sexes were divided into 4 groups, Control, Diabetic control , Diabetic + Ginkgo biloba and Diabetic + Vit E group . Blood urea, serum creatinine and serum uric acid as well as plasma malondialdehyde, superoxide dismutase, catalase, reduced glutathione were estimated and histopathological studies of kidneys were performed. Alloxan at the dose of 120mg/kg i.p, for 2 months at the interval of 14 days, induced diabetes. This prolonged diabetes increased oxidative stress and caused an increase in the levels of serum creatinine, urea, uric acid and plasma malondialdehyde while there were decrease in the levels of superoxide dismutase, catalase and reduced glutathione in diabetic group as compared to normal control group. Histopathological examination revealed hemorrhage, necrosis, and infiltration of leukocytes around the glomerulus and interstitial spaces. Co-administration of Ginkgo biloba 300mg/kg orally, daily for 2 months in diabetic-induced rats caused decreased in the levels of serum creatinine, urea, uric acid and plasma malondialdehyde. Increased levels of superoxide dismutase, catalase and reduced glutathione were also found. The study revealed protective antioxidant activity of Ginkgo biloba in diabetic nephrotoxicity.

Keywords

Diabetes, Oxidative Stress, Nephrotoxicity, Ginkgo biloba.

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M. A. Chaudhari ¹, S. M. Sarode ², Y. A. Chaudhari ³, G. Vidyasagar ², M. K. Kale ⁴

Affiliations
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN

Abstract

Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. Now we are turned in to medicinal plant analysis of active compounds and conservation aspect. In the present study we had select the four important medicinal plants in the Khandesh region. Such plants are widely used in this region for ayurvedic purpose by villagers and local herbal health masters. We have colleted four medicinally important medicinal plants such as Acalypha indica, Cassia auriculata, Eclipta alba and Phyllanthus niruri for antimicrobial studies. The experiment carried out in the selected medicinal plants leaves and ischolar_mains. The results are discussed with the available literature.

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S. V. Chordiya ¹, R. B. Pimprikar ², S. B. Yeshwante ², Tanvir Shaikh ², P. N. Patil ³, M. K. Kale ⁴, B. M. Firke ⁴

Affiliations
1 Varadvinayak Sankul, Flat No-1, Bajrang Chawk, N-8, CIDCO, Aurangabad-431005, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 Science College, Nagaon, Dhule (M.S.), IN
4 KYDSCT,s College of Pharmacy, Sakegaon, Jalgaon (M.S.), IN

Abstract

Worm infestation is one of the major global public health problems, more so in tropical countries. Worms can cause various GI and general symptoms. In addition some of them can cause blood lose, nutritional deficiencies. Helminthiasis is among the most important animal health problems. The disease is highly prevalent particularly in developing countries. In present study Aqueous and ethanolic extract of Hiptage benghalensis (L) kurz, belonging to family Malpighiaceae leaves were investigated for anthelmintic activity. The extracts were used in concertrations of 5, 10 and 25mg/ml and the process involves determination of time of paralysis and time of death of Pheritima posthuma (earth worm). Among the two extracts tested, aqueous extract showed more potent activity against the worm when compared with standard drug Piperazine citrate.

Keywords

Anthelmintic, Hiptage Bengalensis, Piperazine Citrate, Aqueous Extract.

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