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Authors
Affiliations
1 Department of Pharmaceutics and Formulation, Development College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, IN
2 College of Pharmaceutical Sciences, Mohuda, Berhampur-760002, Orissa, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 54-58
Abstract
The pharmacological evaluation of the chloroform extract of Pandanus fascicularis Lamk. leaves was found that it is having antinociceptive and anti-inflammatory properties, and contains the phytoconstituents viz., steroids, terpenoids, flavonoids, saponins and tannins. Therefore tablets were formulated with the extract by wet granulation method. The mechanical properties of the tablets like crushing strength and friability were assessed. The drug release properties were evaluated by using in-vitro disintegration and dissolution methods. There were statistically significant differences (p<0.01) in the crossing strength friability ratio (CSFR) of the tablets. The differences in drug release depend on the types and concentration of the excipients and the binders employed in the formulation. PVP, gelatin and corn starch were used in different concentrations i.e. 1% w/w and 4% w/w with purified water as binder solutions, for the preparation of tablets. The ranking of crushing strength values for tablets was PVP > gelatin > corn starch. The CSFR values also increased with increasing compression force and concentration of binders employed. The ranking of CSFR values for tablets was PVP > gelatin > corn starch. The dissolution time and t80 (time required for 80% release of the extract) were studied with Double beam UV-VIS Spectrophotometer at 271 nm. The ranking of disintegration and dissolution times exhibited by tablets was PVP >gelatin > cornstarch. There was no change in mechanical and drug release properties of the tablets after storage at temperature of 30±2 0C and relative humidity of 75±5% for twelve months.
Keywords
Pandanus fascicularis Lamk. Leaves, Chloroform Extract, Tablets, In-Vitro Evaluation.
