Research Journal of Pharmacognosy and Phytochemistry

Akash P. Dahake ¹, Rita C. Chakma ², Chirantan Chakma ², Deshbandhu Joshi ²

Affiliations
1 Dept. of Pharmaceutical Chemistry, Pharmacy College, Rampura, Godhara, Dist: Panchamahal, Gujarat, IN
2 Pharmacy College, Rampura, Kakanpur, Godhara, Dist. Panchmahal, Gujarat, IN

Abstract

The investigation was carried out to study the antibacterial and antiinflammatory of the Roccella belangeriana (Lichens) in carrageenan induced rat paw oedema im albino rats. Antimicrobial activity of the acetone and aqueous extracts of Roccella belangeriana were determined against various pathogenic bacteria. The extracts were tested against various bacteria like Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli by disk diffusion method. Minimum Inhibitory Concentration (MIC) values of both extracts were determined. It is concluded that acetone extract exhibited significant antimicrobial activity. Acetone extarct of Roccella belangeriana was given at a dose of 100, 200 and 300 mg/kg of body weight (p.o) and standard drug, Diclofenac sodium at a dose of 100 mg/kg. The paw oedema volume was determined for 3 hours at every one hour interwal. The extract exhibited dose dependent activity at all three dose levels. This Study lends sceintific support for it's use in folk medicine.

Keywords

Roccella belangeriana, Carrageenan, Antimicrobial, Anti-Inflammatory.

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Akash P. Dahake ¹, Arun B. Joshi ², Krunal M. Patel ³

Affiliations
1 Dept. of Pharma. Chemistry, B. Pharmacy College, Rampura, Kakanpur, Godhara, Gujarat, IN
2 N.G.S.M Institute of Pharm.Sciences, Paneer, Dearalaktte, Mangalore, IN
3 Pharmacy College, Rampura, Kakanpur, Godhara, Panchmahal, Gujarat, IN

Abstract

Increasing prevalence of multidrug resistant strains of microorganisms has initiated the exploration of alternate antimicrobial agent. Taking into account the medicinal importance of Dolichos Lablab (Fabaceae) in this respect, an attempt was made in the current study to investigate the antimicrobial potential of this plant. Antimicrobial activity of the ethanolic, petroleum ether, aqueous, chloroform, ethyl acetate and nhexane extracts of Dolichos Lablab beans were determined against various pathogenic bacteria and fungi. The extracts were tested against various bacteria like Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and fungi like Candida albicans by disk diffusion method. Minimum Inhibitory Concentration (MIC) values of each active extract were determined. It is concluded that n-Hexane and chloroform extract exhibited significant antimicrobial and antifungal activity.

Keywords

Dolichos Lablab, Antibacterial, Antifungal, Disk Diffusion Method.

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