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Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root


Affiliations
1 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
3 SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India
4 Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, India
     

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Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum root. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.

Keywords

Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.
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  • Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root

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Authors

Vrunda V. Shah
Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India
Vipul K. Shah
Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
Krishnkant N. Patel
SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, India
Navin R. Sheth
Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, India
M. M. Patel
Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India

Abstract


Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum root. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.

Keywords


Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.

References