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Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root
Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum root. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.
Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.
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