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Assessment of Anthelmintic Potential of Averrhoa bilimbi, Clerodendrum viscosum and Drynaria quercifolia: As an Alternative Source for Anthelmintics


Affiliations
1 Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
2 Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
3 College of Medicine, INJE University, Busan, Republic of Korea, Korea, Republic of
     

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Three medicinal plants were presented in this study to investigate the anthelmintic activity using earthworms (Pheretima posthuma).Various concentrations (10 mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml and 50 mg/ml) of three methanolic extracts were tested and results were expressed in terms of time of paralysis and time of death of worms. Albendazole (15 mg/ml) was taken as reference standard and water as control. Paralysis time can be determined by vigorous shaking when no movement was observed. When whitish substances were secreted from the body that one was termed as death time. Dose dependent activity was observed in all extracts but Averrhoa bilimbi showed more activity to Clerodendrum viscosum and Drynaria quercifolia. This is also observed that three plant extracts exhibited more potency than standard.

Keywords

Pheretima posthuma, Albendazole, Dose Dependent Activity, Anthelmintic Activity.
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  • Assessment of Anthelmintic Potential of Averrhoa bilimbi, Clerodendrum viscosum and Drynaria quercifolia: As an Alternative Source for Anthelmintics

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Authors

Md. Ramjan Ali
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
Marjan Hossain
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
Jannatul Ferdous Runa
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
Md. Hasanuzzaman
College of Medicine, INJE University, Busan, Republic of Korea, Korea, Republic of

Abstract


Three medicinal plants were presented in this study to investigate the anthelmintic activity using earthworms (Pheretima posthuma).Various concentrations (10 mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml and 50 mg/ml) of three methanolic extracts were tested and results were expressed in terms of time of paralysis and time of death of worms. Albendazole (15 mg/ml) was taken as reference standard and water as control. Paralysis time can be determined by vigorous shaking when no movement was observed. When whitish substances were secreted from the body that one was termed as death time. Dose dependent activity was observed in all extracts but Averrhoa bilimbi showed more activity to Clerodendrum viscosum and Drynaria quercifolia. This is also observed that three plant extracts exhibited more potency than standard.

Keywords


Pheretima posthuma, Albendazole, Dose Dependent Activity, Anthelmintic Activity.