Research Journal of Pharmaceutical Dosage Form and Technology

Dattatraya M. Shinkar ¹, Sudarshan B. Aher ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal, College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Chemistry, R. G. Sapkal, College of Pharmacy, Anjaneri, Nashik, IN

Abstract

It is suggested here that liquisolid technique has the potential to be optimized for the reduction of drug dissolution rate and thereby production of sustained release systems is possible. In the present study, carvedilol was dispersed in polyethylene glycol 400 as the liquid vehicle. Then a binary mixture of carrier-coating materials ((Avicel PH-102) as the carrier and silica200 as the coating material) was added to the liquid medication under continuous mixing in a mortar. The final mixture was compressed using the tablet compression machine. The effect of drug concentration, loading factor, thermal treating and on release profile of carvedilol from liquisolid compacts were investigated. The release rate of carvedilol from liquisolid compacts was compared to the release of carvedilol from matrix tablets. X-ray crystallography and DSC were used to investigate the formation of any complex between drug and excipients or any crystallinity changes during the manufacturing process. carvedilol tablets prepared by liquisolid technique showed greater retardation properties in comparison with matrix tablets. This investigation provided evidence that (HPMC) hydroxypropyl methylcellulose has important role in sustaining the release of drug from liquisolid tablets. The results also showed that wet granulation had remarkable impact on release rate of carvedilol from liquisolid compacts, reducing the release rate of drug from liquisolid compacts. The results showed that aging (liquisolid tablets were kept at 400C and 75 % relative humidity for 3 months) had no effect on hardness and dissolution profile of drug. The kinetics studies revealed that most of the liquisolid formulations followed the zero-order release pattern. Infrared spectroscopy and DSC ruled out any changes in crystallinity or complex formation during the manufacturing process of liquisolid formulations.

Keywords

Carvedilol, Dissolution Rate, Liquisolid Compacts, Sustained Release.

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Sudarshan B. Aher ¹, Kajal S. Gahide ¹

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN

Abstract

FAST Dissolving Tablet accommodation the organization and enhanced patient consistence are vital in the outline of oral drug delivery framework. which remains the perfect course of drug delivery inspite of different burden of Oral course having the most noteworthy patient consistence is viewed as the most suitable, most secure furthermore the most efficient system for drug delivery. A quick dissolving tablet is one such most beneficial sample of the oral drug delivery. These tablets promptly break up or crumble in the salivation i.e. within 60 sec without the requirement for water. They have been defined for pediatric, geriatric and out of commission patients. These kind of dose structures are likewise perfect for dynamic patients who are occupied and voyaging and might not have entry to water. FDTs have increased generous consideration for those patients who experience issues in gulping on account of dysphagia, hand tremors issues have supplementary playing point for oblivious, youthful patients with immature solid and sensory system. This article endeavors to present a complete survey with respect to innovative advances made so far in the zone of assessment of quick dissolving tablets as for unique qualities of these special measurements structures.

Keywords

Fast Dissolving Tablet, Dysphagia, Superdisintegrants, Patented Technology.

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