Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Abdul Hadi, Mohd
- Formulation and Evaluation of Once Daily Sustained Release Matrix Tablets of Terbutaline Sulphate for the Treatment of Nocturnal Asthma
Abstract Views :619 |
PDF Views:0
Authors
Affiliations
1 Dept. of Pharmaceutics, Bhaskar Pharmacy College, (J.B.I.E.T), Moinabad, R.R District, Hyderabad-500075, A.P., IN
1 Dept. of Pharmaceutics, Bhaskar Pharmacy College, (J.B.I.E.T), Moinabad, R.R District, Hyderabad-500075, A.P., IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 1 (2013), Pagination: 28-33Abstract
Terbutaline sulphate is a 2-adrenergic agonist bronchodilator and used to treat bronchospasm associated with lung diseases such as asthma, bronchitis, and emphysema. Bioavailability of terbutaline sulphate about 14.8 %. The drug half-life is 3-4 hrs. In nocturnal asthma, lung function is usually highest at 4 PM and lowest at 4 AM, the latter time is generally when asthma symptoms are most prevalent. Based on these findings drug delivery and therapy should be modified to achieve an effective drug level at the required time. This can be achieved by adapting a sustained drug delivery system of a suitable drug which when administered during night releases the drug till early morning hours. So, in order to improve bioavailability and efficacy we have designed once a day sustained release tablets of terbutaline sulphate. The tablets were prepared by wet granulation technique using HPMC K200M, Ethylcellulose and combination of both. The sustained release tablets were subjected to preformulation studies, in- vitro drug release, postcompression studies, kinetic studies and stability studies. FTIR studies shown there was no interaction between drug and polymers. The percentage of drug content from the tablets was determined by UV-Spectroscopy and ranged from 97.20±0.50 to 99.12±0.92. The in-vitro percentage release of terbutaline sulphate from the optimized tablets at the end of 24hrs was 99.69±0.91 %. The kinetic studies revealed that the drug was released by first-order kinetics. The optimized formulation was subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern.Keywords
Terbutaline Sulphate, Nocturnal Asthma, Sustained Drug Delivery System, Wet Granulation Technique, HPMC K200M, Ethylcellulose.
References
- Shivakumar, HN, Sarasija Suresh, Desai, BG., Design and evaluation of PH sensitive Mini-tablets for chronotherapeutic delivery of theophylline. Indian Journal of pharmaceutical science-2007; 69: 73-79.
- Janugade, B.U., Patil, S.S., Patil, S.V., Lade, P.D. Formulation and evaluation of press-coated montelukast sodium tablets for pulsatile drug delivery system. International journal of chem. Tech research 2009; 1(3): 690-691.
- Murthy SN and Hiremath SR. Physical and Chemical Permeation Enhancers in Transdermal Delivery ofTerbutaline Sulphate: AAPS PharmSciTech: 2001; 2.
- Vaidya VM, Manwar JV, Mahajan NM, and Sakarkar DM. Design and In- Vitro Evaluation of Mucoadhesive Buccal Tablets of Terbutaline Sulphate. Int. J.PharmTech Research: 2009; 1(3): 588-597.
- Chanda R, Ghosh A, Biswas S and Chowdhury SR. Formulation of oral mucoadhesive tablets of terbutaline sulphate using some natural materials and in-vitro and in-vivo evaluation. Journal of Pharmaceutical Research and Health Care: 2010; 2(1): 32-45.
- Martindale, The complete drug reference,35th edition, edited by Sean C Sweetman, Pharmaceutical Press, US 2007: 1021.
- Rangaswamy M, Ayyasamy B, Raju S, Gummadevelly S. Design and Evaluation of Fast Dissolving Tablet of Terbutaline Sulfate. Asian pharmaceutics: 2010; 3(3): 215-217.
- Mohd Abdul Hadi, Lokeswara Babu V, Narottam Pal, Srinivasa Rao V. Formulation and evaluation of Sustained release Matrix tablets of Montelukast Sodium. International Journal of Pharmacy. 2012; 2(3): 574-582.
- Mohd Abdul Hadi, Lokeswara Babu V, Narottam Pal. Formulation and evaluation of sustained release matrix tablets of glimepiride. Journal of Applied Pharmaceutical Sciences. 2012: 02 (06); 101-107.
- Rakesh Patel, Ashok Baria. Formulation development and process optimization of theophylline sustained release matrix tablet. 2009; 1(2): 30-42.
- Raghavendra Rao NG, Harsh Panchal, Mohd Abdul Hadi. Development and evaluation of matrix tablet filled capsule system for chronotherapeutic delivery of Terbeutaline sulphate. World Journal of Pharmaceutical Research. 2012: 1(3); 757-775