Open Access Subscription Access
Open Access Subscription Access
A Comprehensive Note on Gastro-Retentive Dosage Forms
Controlled release drug delivery system has achieved greater importance in the field of pharmaceutical sciences to provide therapeutic advantages over the conventional drug delivery system. Nowadays, the gastrointestinal controlled drug delivery system is more prominent than the controlled release system because these can govern the release rate of therapeutically active drug for a sustained period. A Gastro retentive dosage form improves the therapy by prolonging the gastric residence time of the drugs. Prolonged gastric retention improves bioavailability, reduces drug waste and improves solubility for drugs that are less soluble in a high pH environment.In this review, we have discussed various systems associated with gastro retentive drug delivery with their effective mode of action. Also, the approaches and factors to increase the gastric retention time have also been discussed. This drug delivery system has potential to overcome the limitations of the conventional system. The present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.
Gastro-Retentive, Controlled Drug Delivery, Floating Drug Delivery, Mucoadhesion.
- Jain N.K, "Advances in Controlled & Novel Drug Delivery," CBS Publishers & Distributers, New Delhi, Pg 76-95
- Timmermans J, Moes AJ. How Well Floating Dosage Form Float?. Int J Pharm 1990; 62:207‐16.2.
- Strebeul A, Siepmann J & Bodmeier R, Gastro retentive drug delivery system, Expert Opin Drug Deliv, 3 (2006) 217.
- Garg Sanjay; Sharma Shringi. Business Briefing Pharmtech, 2003, 160-166. Sangekar S. International Journal of Pharmaceutics, 1987, 35(3), 34-53.
- Neena Washington, Clive Washington and Clive G.Wilson , Physiological Pharmaceutics Barriers to drug absorption, Second Edition, 2001, 81-90.
- Patel R. Recent development in floating drug delivery system for gastric retention of drugs: an overview. 2007; http://www.swatijaininst.com/etechno/feb2007/roma.rtf 26.
- Asane GS. Mucoadhesive gastrointestinal drug delivery system: An overview. 2007; www.pharmainfo.net. 27.
- I Krogel and R Bodomeier, Floating or pulsatile drug delivery systems based on coated effervescent cores. Int J Pharm; 187; 1999; 175-184.
- P R Sheth, J L Tossounian J L, Sustained release pharmaceutical capsules. US Pat 4; 126; 672; November 21, 1978.
- S Desai and S Bolton, A controlled release drug delivery system: In vitro-in vivo evaluation. Pharm Res; 10; 1993; 1321-1325.
- P Dennis, K Timmins, S Lee, Buoyant controlled release powder formulation. US Pat 5; 169; 638; December 8, 1992.
- R M Harrigan, Drug delivery device for preventing contact of undissolved drug with the stomach lining. US Pat 4, 055; 178; October 25, 1977
- Prajapati, S.T., Patel, L.D. and Patel, D.M. Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone. Indian J Pharm Sci, 2009, Vol. 71(1), pp. 19-23
- Bhavna V, Khopade AJ, Shelly WD and Jain NK: Targeted oral drug delivery. Indian Drugs 1996; 33: 365-373.
- Shah S.H., Patel J.K., Patel N.V.; stomach specific floating drug delivery syatem; IJPTR;2009, pp. 629-630.
- Rajab, M., Jouma, M., Neubert, R.H. and Dittgen, M. Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid. Pharmazie, 2010, Vol. 65(2), pp. 97-101.
- Jagdale, S.C., Agavekar, A.J., Pandya, S.V., Kuchekar, B.S. and Chabukswar, A.R. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS PharmSciTech, 2009, Vol. 10(3), pp. 1071-1079.
- Bomma, R., Naidu, R.A.S., Yamsani, M.R. and Veerabrahma, K. Development and evaluation of gastroretentivenorfloxacin floating tablets. Acta Pharm, 2009, Vol. 59(2), pp. 211-221.
- Patel, A., Modasiya, M., Shah, D. and Patel, V. Development and in vivo floating behavior of verapamil HClintragastric floating tablets. AAPS PharmSciTech, 2009, Vol. 10(1), pp. 310-315.
- Arza, R.A.K., Gonugunta, C.S.R. and Veerareddy, P.R. Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets. AAPS PharmSciTech, 2009, Vol. 10(1), pp. 220-226.
- Garg, R. and Gupta, G.D. Preparation and evaluation of gastroretentive floating tablets of acyclovir. Curr Drug Deliv, 2009, Vol. 6(5), pp. 437-443.
- Sawicki, W., ?unio, R., Walentynowicz, O. and KubasikJuraniec, J. aInfluence of the type of cellulose on properties of multi-unit target releasing in stomach dosage form with verapamil hydrochloride. Acta Pol Pharm, 2007, Vol. 64(1), pp. 81-88.
- Goole, J., Deleuze, P., Vanderbist, F. and Amighi, K. New levodopa sustained-release floating minitablets coated with insoluble acrylic polymer. Eur J Pharm Biopharm, 2008, Vol. 68(2), pp. 310-318.
- Meka, L., Kesavan, B., Chinnala, K.M., Vobalaboina, V. andYamsani, M.R. Preparation of a matrix type multiple-unit gastro retentive floating drug delivery system for captopril based on gas formation technique: in vitro evaluation. AAPS PharmSciTech, 2008, Vol. 9(2), pp. 612-619.
- Zhai, X.-L., Ni, J. and Gu, Y.-L. Study on preparation of phenols gastric floating tablet ZhongguoZhong Yao ZaZhi, Beijing University of Traditional Chinese Medicine, Beijing 100102, China., 2008, Vol. 33(1), pp. 31-34.
- Vyas SP, Khar RK. Gastroretentive systems. In: Controlled drug Delivery. VallabhPrakashan, Delhi, India. 2006. pp. 197-217.
- Chawla G, Gupta P, Bansal AK. Gastroretentive drug delivery systems. In: Jain NK. editor. Progress in controlled and novel drug delivery systems. CBS Publishers and Distributors. New Delhi. 2004. p. 76-97.
- Vinod KR, Vasa S, Anbuazagahan S. Approaches for gastroretentive drug delivery, IJABPT, 2008; 589-601.
- Pawar V.K, Shaswat K, Garg G, Awasthi R. Gastroretentive dosage form: A review with special emphasis on floating drug delivery systems, Informa Healthcare 2011; 18(2): 97-110 9.
- Dixit N. Floating drug delivery system. Journal of Current Pharmaceutical Research, 2011 ;7(1):6-20.
- Vyas SP, Khar RK. Controlled drug delivery: concept and advances. Vallabhprakashan Delhi, 2002; 1: 123-231.
- Solanki ND, Shah S, Patel J, Upadhyay P. Formulation and evaluation of once bilayer floating tablets of antihypertensive drug involving dissolution enhancement technique. Der Pharmacia Sinica, 2013; 4(5): 54-66.
- Bhowmik D, Chiranjib B, Jayakar B. Floating drug delivery system- a review. Der Pharmacia. Lettre, 2009; 1(2): 199-218.
- Chander S, Shireesh K, Nagendra B. Preparation and evaluation of gastroretentive floating tablets of ketoconazole. IJPRD, 2010; 2(9): 175-176.
- Chandel A, Chauhan K. Gastroretentive approaches. ICPJ 2012;1:110-118.
- Khan AZ, Tripathi R, Mishra B. Floating elementary osmotic pump tablet for controlled d delivery of diethylcarbamazine citrate: a water- soluble drug. AAPS Pharm Sci Tech, 2011;12(4):1312-1323.
- SubhramananyamCVS ,Setty JT. Laboratory manual of physical pharmaceutics. Vallabhprakashan 2002;pg no 212.
- Pamu S, Banu N, Sunitha M. Formulation and evaluation of olmesartanmedoxomil floating tablets. International Journal of Pharmacy and Industrial Research, 2013;3(4):329-334.
- Vedha BN, Brahma RA, Samyuktha RB. Floating drug delivery of Nevarapine as a gastroretentive system. Journal of Yung Pharmacist, 2010;2(4)350-355.
- Boldhane SP and Kuchekar BS. Development and optimization of metoprolol succinate gastroretentive drug delivery system. Acta Pharm, 2010;60:415-425.
Abstract Views: 1
PDF Views: 0