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Formulation Aspects Behind the Development of a Stable Biphasic Liquid Dosage Form with Special Reference to Microemulsion: A Review


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1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
     

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A plethora of research and industrial processes used microemulsion system after its discovery by Jack H. Shulman. The microemulsionis defined as clear, stable, isotropic mixtures of oil, water, and surfactant, frequently in combination with a co-surfactant. They are solutions of oil, water,andamphiphile which are optically isotropic and thermodynamically stable. The aqueous phase present in the system contains salt(s) and other ingredients while the "oil" phase mainly forms a complex of different hydrocarbons and olefins. They do not require high shear conditions as compared to ordinary emulsions. Hence they are easy to prepare. Ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability to solubilize immiscible liquids are some of its unique properties. They also show the ability to protect labile drug, control drug release, increase drug solubility, increase bioavailability and reduce patient variability. Hence, microemulsion has gained most significance in both basictypes of research as well as in industry. They have wide applications and uses such as in pharmaceuticals, cosmetics, cutting oils, biotechnology, food, agrochemicals, environmental detoxification, analytical applications, microporous media synthesis, etc. The microemulsion can be effectively used in dermal delivery because of its mechanism, hence can be used in pharmaceutical and cosmetics preparation. Microemulsion enhances the dermal absorption as they allow rapid penetration of active molecules due to the large surface area of the internal phase and their components reduce the barrier of stratum corneum. Thus, microemulsionisa promising vehicle for effective drug delivery. The current review article deals with information about the microemulsion. Also, the present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords

Microemulsion, Thermodynamically Stable, Bioavailability.
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  • Formulation Aspects Behind the Development of a Stable Biphasic Liquid Dosage Form with Special Reference to Microemulsion: A Review

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Authors

Amrita Thakur
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Nisha Nair
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Mukta Agrawal
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Yashi Thakur
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Juhi Thakur
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Teman Nirmalkar
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Ved Prakash Verma
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Vibhash Gupta
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Vivek Singh Yadav
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Kalpana Mahilange
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Pooja Mahant
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Pritam Yadav
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Deepak Patel
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Dinesh Khamari
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Jyotsana Meshram
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Rakesh Sahu
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Tarun Ghatode
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
D. K. Tripathi
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Ajazuddin
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India
Amit Alexander
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai - 490024, Chhattisgarh, India

Abstract


A plethora of research and industrial processes used microemulsion system after its discovery by Jack H. Shulman. The microemulsionis defined as clear, stable, isotropic mixtures of oil, water, and surfactant, frequently in combination with a co-surfactant. They are solutions of oil, water,andamphiphile which are optically isotropic and thermodynamically stable. The aqueous phase present in the system contains salt(s) and other ingredients while the "oil" phase mainly forms a complex of different hydrocarbons and olefins. They do not require high shear conditions as compared to ordinary emulsions. Hence they are easy to prepare. Ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability to solubilize immiscible liquids are some of its unique properties. They also show the ability to protect labile drug, control drug release, increase drug solubility, increase bioavailability and reduce patient variability. Hence, microemulsion has gained most significance in both basictypes of research as well as in industry. They have wide applications and uses such as in pharmaceuticals, cosmetics, cutting oils, biotechnology, food, agrochemicals, environmental detoxification, analytical applications, microporous media synthesis, etc. The microemulsion can be effectively used in dermal delivery because of its mechanism, hence can be used in pharmaceutical and cosmetics preparation. Microemulsion enhances the dermal absorption as they allow rapid penetration of active molecules due to the large surface area of the internal phase and their components reduce the barrier of stratum corneum. Thus, microemulsionisa promising vehicle for effective drug delivery. The current review article deals with information about the microemulsion. Also, the present study is performed for the motivation of the graduates towards publication and research. Hence, we have encouraged the graduates to prepare an informative article on the present subject.

Keywords


Microemulsion, Thermodynamically Stable, Bioavailability.

References