Research Journal of Pharmaceutical Dosage Form and Technology

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Formulation and Evaluation of Ondansetron Floating Tablet


Affiliations
1 Department of Pharmaceutics, Sardar Patel College of Technology (B. Pharmacy), Balaghat, M.P., India
     

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Some drugs are absorbed in a particular portion of the GIT only or are absorbed to a different extent in various segments of the GIT. Such drugs are said to have an absorption window, which identifies the drug’s primary region of absorption in the GIT. Gastroretentive tablets of Ondansetron hcl were successfully prepared by effervescent technique using different gel forming polymers- HPMC (K15M, K4M, 15cps, 3cps), and carbopol 934. Formulation was optimized on basis of floating time and in vitro release. The prepared gastroretentive test formulation was found to exhibit satisfactory physico-chemical characteristics at the end of 30 days, during the stability studies. The optimized formulation was found to be stable at 400C/ 75% RH.

Keywords

Absorption Window, Effervescent Technique, HPMC, Carbopol 934, Floating Time, Stability Studies.
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  • Formulation and Evaluation of Ondansetron Floating Tablet

Abstract Views: 198  |  PDF Views: 0

Authors

Lokesh Patle
Department of Pharmaceutics, Sardar Patel College of Technology (B. Pharmacy), Balaghat, M.P., India

Abstract


Some drugs are absorbed in a particular portion of the GIT only or are absorbed to a different extent in various segments of the GIT. Such drugs are said to have an absorption window, which identifies the drug’s primary region of absorption in the GIT. Gastroretentive tablets of Ondansetron hcl were successfully prepared by effervescent technique using different gel forming polymers- HPMC (K15M, K4M, 15cps, 3cps), and carbopol 934. Formulation was optimized on basis of floating time and in vitro release. The prepared gastroretentive test formulation was found to exhibit satisfactory physico-chemical characteristics at the end of 30 days, during the stability studies. The optimized formulation was found to be stable at 400C/ 75% RH.

Keywords


Absorption Window, Effervescent Technique, HPMC, Carbopol 934, Floating Time, Stability Studies.

References