Research Journal of Pharmaceutical Dosage Form and Technology

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Bicalutamide Tablets by Spray Dried Microspheres:An Approach to Enhance Solubility


Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
     

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The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

Keywords

Solubility, Bicalutamide, Prostate Cancer, Microspheres, Tablets.
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  • M. V. Srikanth, B. Janaki. Ram, D. Senthil. Rajan, G. Adinarayana, K. V. Ramanamurthy., Dissolution rate enhancement of Bicalutamide by adsorption process: African Journal of Pharmacy and Pharmacology, 2013; 7(21), 13571362.

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  • Puckhraj Chhaprel, Amit Talesara, Amit K Jain., Solubility enhancement of poorly water soluble drug using spray drying technique: International Journal of Pharmaceutical Studies and Research, 2012; 3(2),01-05.

  • B. Janaki Ram, D. Senthil Rajan, G. Adinarayana1 and K. V. Ramana Murthy., Dissolution rate enhancement of Bicalutamide by adsorption process; African Journal of Pharmacy and Pharmacology, 2013; 7(21), 1357-1362.


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  • Bicalutamide Tablets by Spray Dried Microspheres:An Approach to Enhance Solubility

Abstract Views: 196  |  PDF Views: 0

Authors

Rutuja R. Shah
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Abhijeet Jadhav
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India
Rohan R. Vakhariya
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India

Abstract


The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

Keywords


Solubility, Bicalutamide, Prostate Cancer, Microspheres, Tablets.

References