Research Journal of Pharmaceutical Dosage Form and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems:A Review


Affiliations
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., India
2 Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, India
4 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, India
5 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, India
     

   Subscribe/Renew Journal


Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.

Keywords

Osmotic Drug Delivery System, Osmosis, Osmotic Pressure.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Parmar NS, Vyas SK, Vaya N. Osmotic Pump A Novel Drug Delivery System. In: Jain NK, Editors. Advances in controlled and novel drug delivery systems. New Delhi: CBS Publishers and distributors;2004,p.18-37.

  • Li X and Jasti BR. Osmotic controlled drug delivery systems, In: Designof controlled release of drug delivery systems, McGraw Hill, 2006; p.203-229.

  • Verma RK, Garg S. Current status of drug delivery technologies and future directions. Pharma Technol On line(http://www.pharmaportal.com) 2001;25:1-14.

  • Malaterre V, Ogorka J, Loggia N, Gunny R. Oral osmotically driven systems:30 years of development and clinical use Eur. J. Pharm. Biopharm. 2009;73:311-323.

  • Madhavi BB, Nath AR, Banji D. Ramalingam R, Madhu MN and Kumar DS. Osmotic drug delivery system :a review. Pharmakine 2009;2:5-14.

  • Kaushal AM and Garg S: An update on osmotic drug delivery patents. Pharm. Tech.,2003, 27, 38-44

  • Verma RK, Arora S, Garg S. Osmotic pumps in drug delivery Critical Review in Therapeutic Drug Carrier Systems 2004;21(6):477-520.

  • Singh K, Walia MK, Agarwal G, Harikumar SL. Osmotic pump drug delivery system: a novel approach Journal of Drug Delivery and Therapeutics 2013;3(5):156-162.

  • Grattoni A, Merlo M, Ferrari M. Osmotic pressure beyond concentration restrictions J. Phys. Chem. B 2007;111:11770-11775.

  • Herrlich S, Spieth S, Messner S, Zengerle. Osmotic micropumps for drug delivery. Advanced Drug Delivery Reviews.2012;64:1617-1627.

  • Theeuwes F. Elementary osmotic pump J.Pharm.Sci.1975;64:1987-1991.

  • Verma RK, Krishna DM and Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J Control Release 2002;79:7-27.

  • Rose S, Nelson J.A Continuous long term injector Aust.J.Exp.Biol.Med.Sci.1955;33:415-421.

  • Higuchi T and Leeper HM. Improved osmotic dispenser employing magnesium sulfate and magnesium chloride.US Patent3760804 ;1973.

  • Theeuwes F, Higuchi T, Inventors; Alza corporation, Palo Alto, CA, Assignee. Osmotic dispensing device for releasing beneficial agent.US Patent;1974,3845770.

  • ALZET Osmotic pumps http://www.alzet.com/research_applications.

  • Wright JC, Johnoson RM and Yum SI. Duros Osmotic Pharmaceutical Systems for Parenteral and Site Directed Therapy. Drug. Deliv. Technol 2003;3:3-11

  • Prajapati HM, Prajapati ST, Patel CN.A review on recent innovation in osmotically controlled drug delivery system. Int. J of Pharma. Research and Bioscience 2012;1(3):158-194.

  • Mishra B, Makesh BK and Sankar C.Oral push pull osmotic pumps of pentazocine hydrochloride development and evaluation. Ind. J Pharm Sci.,2006;68(1):85-87.

  • Srenivasa B, Kumar NR, Murthy KVR. Development and in vitro evaluation of osmotically controlled oral drug delivery system. Easstern Pharmacist 2001;22.

  • Zentner GM, Rork GS, Himmelstein KJ. The controlled porosity osmotic pump. J Control Release 1985;1(4):269-282.

  • Padma priya S, Ravichandram V, Suba V.A review on osmotic drug delivery system. Int. J of Research in Pharmaceutical and Biomedical Sciences 2013;4(3):810-821.

  • Dong L ,Wong P and Espinal S. loros hardcap: A new osmotic delivery system for controlled release of liquid formulations: In :Proceedings of the International Symposium on controlled release of biomedical materials, San Dieego;2001.

  • Sareen R, Jain N and Kumar D. An insight to osmotic drug delivery. Curr Drug Deliv. 2012;9(3):285-96.

  • Theewes F, Wong PSL, Burkoth TL, Fox DA and Bicek PR. Colonic drug absorption and metabolism. Marcel Decker, New York;1993,pp137-158.

  • Lee HB, Liu L, Ku J, Khang G, Lee B and Rhee JM. Nifedipine controlled delivery sandwiched osmotic tablet system ,J Control Release 2000;68:145-156.

  • Liu L and Wang X. Solubility modulated monolithic osmotic pump tablet for atenolol delivery. Eur J Pharm Biopharm 2008;68(2):298-302.

  • Thakor RS, Majmudar FD, Patel JK and Rajput GC. Osmotic drug delivery systems current scenario. Journal of Pharmacy Research 2010;34:771-775.

  • Schultz P, Kleinebudde P.A new multiparticulate delayed release system Part I Dissolution properties and release mechanism. J Control Release 1997;47:181-189.

  • Ramdan MA, Tawashi R. The effect of hydrodynamic conditions and delivery orifice size on the rate of drug release from elementary osmotic pump system. Drug Dev Ind Pharm 1987;13(2):235-248.

  • Arora S, Ali J, Ahuja A, Baboota S and Qureshi J. Pulsatile drug delivery systems an approach for controlled drug delivery. Ind. J.Pharm.Sci.2006;68(3):295-300.

  • Godbillion JH, Gerardin A, Richard J, Leroy D, Moppert J. Osmotically controlled delivery of metoprolol in man in vivo performance of oros system with different duration of drug release.Br.J.Clin.Pharma.1985;19:69S-76S.

  • Kumar L, Shivani, Kumar A, Parashar D, Bhadra S. Asymmetric membrane capsule(AMC):an useful osmotic drug delivery system Int J. Pharm Pharm Sci.2012;4(2):54-59.

  • Swanson DR, Barclay BR, Wong PSL et.al. Nifedipine gastrointestinal therapeutic system.Am.J.Med.1987;83(6B):3-9.

  • Thombre AG, DeNoto AR, Gibbes DG. Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients. J. Cont. Rel. 1999;60:333-341.

  • Bauer K, Kaik G, Kaik B. Osmotic release oral drug delivery system of metoprolol in hypertensive asthmatic patients, Pharmacodynamic effects on beta 2-adrenergic receptors. Hypertension 1994;24:339-346.

  • Vyas SP, Khar RK. Controlled drug delivery:concept and advances. Vallabh prakashan,NewDelhi;2001,477-501.

  • Khavare NB, Dasankoppa SF, Najundaswamy NG.A review on key parameters and components in designing of osmotic controlled oral drug delivery systems. Indian J of Novel Drug Delivery 2010;2(4):122-131.

  • Jerzewski Rand Chien Y. Osmotic drug delivery, In:Treatise on controlled drug delivery:Fundamentals, optimization, Application. Marcel Dekker;1992,225-253.

  • Verma RK, Mishra B, Garg S. Osmotically controlled oral drug delivery. Drug Dev Ind Pharm 2000;26:695-708.

  • Patel H, Patel U, Kadikar H, Bhimani B, Daslaniya D, Patel G. Areview on osmotic drug delivery system. Int. Res J of Pharm 2012;3(4):89-94.

  • Mahalaxmi R, Phanidhar, Sastri, Ravikumar, Atin Kalra, Pritam Kanagale and Narkhede. Enhancement of Dissolution of Glipizide from controlled porosity osmotic pump using wicking agents and a solubilizing agent. Int. J. Pharm Tech Res.2009;1(3):705-711.

  • Guo J. An investigation into formation of plasticizer channels in plasticized polymer films. Drug Dev.Ind.Pharm.1994;20:1883-1893.

  • Kelbert M, Bechard SR. Evaluation of cellulose latex as coating material for controlled release products. Drug Dev. Ind Pharm 1992;18:519-538.

  • Dong LC, Espinal S, Wong PSL. Inventors Alza corporation Mountain View CA Assignee. Dosage form comprising liquid formulation .US Patent 6174547.Jan16;2001.

  • Theeuwes F, Saunders RJ, Mefford WS. Process for forming outlet passageways in pills using a laser US Patent 4088864,May 9,1978.

  • Chen C, Lee D, Xie J. Controlled release formulation for water insoluble drugs in which a passageway is formed in situ.US patent 5736159 April 7,1998.

  • Ayer AD, Balkie HH. Method and apparatus for forming a hole in a drug dispensing device.US Patent 5071607 Dec10,1991.

  • Haslam JL. Rork GS. Controlled porosity osmotic pump.US4880631 Patent Nov 14,1989.

  • Rudine EM, Burnside BA, Flanner HH, Wassink SE, Couch RA, Pinkett JE. drug delivery system US patent 6,110,498 Aug.29,2000.

  • Zentner GM, McClelland, Sutton SC. Controlled porosity solubility and resin modulated osmotic drug delivery systems for release of diltiazem hydrochloride J Control. Release 1991;16:237-244.

  • Khanna SC. Therapeutic system for sparingly soluble active ingredients US patent 4,992,278,Feb.12.1991.

  • Theewes F. Osmotic dispenser with gas generating means.US patent 4,036,228 July 19,1977.

  • Okimoto K, Miyake M, Ohnishi N, Rajewski RA, Stella VJ, Irie T, Uekama K. Design and evaluation of an osmotic pump tablet for prednisolone a poorly water soluble drug using (SBE)-7m- ᵝ-CD.Pharm.Res.1998;15:1562-1568.

  • Theeuwes F, Swanson DR, Guittard G, Ayer A, Khanna S. Osmotic delivery systems for the beta-adrenoceptor antagonists metoprolol and oxprenolol :design and evaluation of systems for once-daily administration Br. J. Clin. Pharmacol. 1985;19:69S76S.

  • Thombre AG, DeNoto AR, Gibbs DC. Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients J. Control. Release. 1999;60:333-341.

  • Koparkar AD, Shah SB. Oral osmotic system for slightly soluble active agents US patent 5,284,662,Feb.8,1994

  • McClelland, Sutton SC, Engle K, Zentner GM. The solubility modulated osmotic pump In vitro/in vivo release of diltiazem hydrochloride Pharm.Res.1991;8:88-92.

  • Curatolo WJ. Dispensing devices powered by lyotropic liquid crystals US patent 5,108,756 April28,1992.

  • Ghosh Tanmoy, Ghosh Amitav. Drug delivery through osmotic systems an overview. J. of Applied Pharmaceutical science 2011;01(2):38-49.

  • Keraliya AR, Patel C, Patel P, Keraliya V, Soni GT, Patel CR and Patel MM. Osmotic drug delivery system as a part of modified release dosage form. Int. Scholarly Research Network 2012;2012:1-9.

  • Theeuwes F. Microporous semipermeable laminated osmotic system, Alza corporation.1981;US Patent no4256108

  • Ayer AD, Theeuwes F. Osmotic system for dispensing drugs, Alza corporation.1981;US Patent no4285987.

  • Zentner GM, Rork GS, Himmnelstein KJ. Controlled porosity osmotic pump, Merck and Co.1986; EP Patent no. 0169105.

  • Athayde AL, Faste RA, Horres Jr. CR, Low TP. Controlled release osmotic pump, Recordati corporation, US Patent no.5672167.

  • Haslam JL, Rork GS. Controlled porosity osmotic enalpril pump, Merck and Co.Inc.1994;WO Patent no.1994001093.

  • Haslam JL, Rork GS. Controlled porosity osmotic pump, Merck and Co.Inc.1992;EP Patent no.0309051.

  • Haslam JL, Rork GS. Controlled porosity osmotic pump, Merck and Co.Inc.1991;CA Patent no.1320885.

  • Debusi LA, Ruddy SB, Storey DE. Osmotic controlled release drug delivery device, Merck and Co.Inc.2001;WO Patent no.2001032149.

  • Hood LE, Ishikawa MY, Jung EKY, Langer R, Clarence T, Wood TLL, Wood VYH. Osmotic pump with remotely controlled pressure generation The Invention Science Fund Lic.2012,US Patent no.8109923.

  • Mccelland GA, Zentner GM. Solubility modulated drug delivery system Merck and Co.Inc.1990;US Patent no.4946686.

  • Theeuwes F. Osmotic device having micro porous reservoir, Alza corporation 1976;US Patent no.3977404.

  • Patel NK, Mehta TA.A review on oral osmotically driven systems Int. J Pharm Pharm Sci2013; 5(3):1005-1013.


Abstract Views: 216

PDF Views: 0




  • Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems:A Review

Abstract Views: 216  |  PDF Views: 0

Authors

Chinmaya Keshari Sahoo
Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., India
Surepalli Rammohan Rao
Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia
Muvvala Sudhakar
Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, India
D. Venkata Ramana
Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, India
Kanhu Charan Panda
Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, India

Abstract


Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.

Keywords


Osmotic Drug Delivery System, Osmosis, Osmotic Pressure.

References