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Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix


Affiliations
1 Department of Pathology, College of Medicine, Omdurman Islamic University, 382 Omdurman, Sudan
2 Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia
3 College of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
 

Cervical cancer is one of the commonest types of cancers worldwide especially in developing countries. Intermediate filaments protein family has shown a role in the diagnosis of various cancers, but a fewstudies are available about the vimentin and cytokeratin roles in the cervical cancer. This case control study aimed to interpret the expression of vimentin and cytokeratin proteins in the development and progression of cervical cancer and its correlation with clinicopathological features. The cytoplasmic expression of vimentin was observed in 40% of cases, but not in inflammatory lesions of cervix. It was noticed that vimentin expression was increasing significantly with high grade of the tumour. Cytokeratin expression was observed in 48.33% and it was noticed that the expression was 62.5% in well differentiated (G1), 45% in moderately differentiated (G2), and 41.66% in poorly differentiated carcinoma, yet statistically insignificant. The expression of vimentin and cytokeratin proteins was not significantly associated with age groups. The current findings concluded a possible role of vimentin in the development and progression of cervical cancer and vimentin marker will be useful in the diagnosis and grading of cervical cancer.
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  • Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix

Abstract Views: 95  |  PDF Views: 0

Authors

Nazik Elmalaika O. S. Husain
Department of Pathology, College of Medicine, Omdurman Islamic University, 382 Omdurman, Sudan
Ali Yousif Babiker
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia
Aqel S. Albutti
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia
Mohammed A. Alsahli
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia
Salah M. Aly
College of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
Arshad H. Rahmani
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia

Abstract


Cervical cancer is one of the commonest types of cancers worldwide especially in developing countries. Intermediate filaments protein family has shown a role in the diagnosis of various cancers, but a fewstudies are available about the vimentin and cytokeratin roles in the cervical cancer. This case control study aimed to interpret the expression of vimentin and cytokeratin proteins in the development and progression of cervical cancer and its correlation with clinicopathological features. The cytoplasmic expression of vimentin was observed in 40% of cases, but not in inflammatory lesions of cervix. It was noticed that vimentin expression was increasing significantly with high grade of the tumour. Cytokeratin expression was observed in 48.33% and it was noticed that the expression was 62.5% in well differentiated (G1), 45% in moderately differentiated (G2), and 41.66% in poorly differentiated carcinoma, yet statistically insignificant. The expression of vimentin and cytokeratin proteins was not significantly associated with age groups. The current findings concluded a possible role of vimentin in the development and progression of cervical cancer and vimentin marker will be useful in the diagnosis and grading of cervical cancer.